Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption.

Author: BoPing, FangPenghua, HeBiao, ShiMingyi, YuMei, ZhangZhenwen, ZhuYan

Paper Details 
Original Abstract of the Article :
Overweight and obesity may cause several metabolic complications, including type 2 diabetes mellitus and hyperlipidemia. Despite years of progress in medicine, there are no highly effective pharmacological treatments for obesity. The natural compound celastrol, a pentacyclic triterpene extracted fro...See full text at original site
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引用元:
https://doi.org/10.1016/j.bbadis.2019.02.002

データ提供:米国国立医学図書館(NLM)

Celastrol: A Potential New Weapon Against Obesity

Obesity is a complex health issue with a growing prevalence globally. This study explores the potential of celastrol, a natural compound found in the thunder god vine plant, as a therapeutic agent for obesity. The researchers investigated the mechanisms behind celastrol's anti-obesity effects, revealing its ability to suppress fat intake and enhance glucose consumption. The study provides promising findings for the development of novel treatments for obesity.

Celastrol: A Promising Approach to Weight Management

Celastrol, like a desert plant thriving in harsh conditions, demonstrates its ability to combat obesity. The study shows that celastrol not only reduces fat intake but also enhances glucose consumption, offering a multi-pronged approach to weight management. The findings suggest that celastrol could be a valuable addition to the arsenal against obesity, a global health challenge.

Unlocking Nature's Secrets for Weight Control

The research on celastrol highlights the potential of natural compounds for tackling obesity. It's like discovering a hidden oasis in the vast desert of obesity research, offering a refreshing perspective on weight management. Further research is needed to determine the optimal dosage and potential long-term effects of celastrol, but the initial findings are encouraging.

Dr.Camel's Conclusion

This research on celastrol provides a compelling glimpse into the potential of natural compounds for obesity management. It's like finding a rare desert flower with incredible healing properties. While further exploration is necessary, the research offers a promising avenue for developing new therapeutic approaches to combat obesity.

Date :
  1. Date Completed 2020-02-03
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30742994

DOI: Digital Object Identifier

10.1016/j.bbadis.2019.02.002

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SNS
PICO Info
in preparation
Languages

English

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