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pH-Dependent Uptake and Sublethal Effects of Antihistamines in Zebrafish (Danio rerio) Embryos.
Author: BittnerLisa, EscherBeate I, KeddiIsabel, KlüverNils, TeixidóElisabet
Original Abstract of the Article :
Reported off-target effects of antihistamines in humans draw interest in ecotoxicity testing of first- and second-generation antihistamines, the latter of which have fewer reported side effects in humans. Because antihistamines are ionizable compounds, the pH influences uptake and toxicity and thus ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/etc.4395
データ提供:米国国立医学図書館(NLM)
Antihistamines in Zebrafish Embryos: A Tale of pH-Dependent Toxicity
The field of [ecotoxicology] is a fascinating and complex desert, where researchers explore the impact of chemicals on the environment. This research investigates the [toxicity] of [antihistamines] in [zebrafish] embryos, examining the influence of pH on their uptake and effects. The authors discovered that [antihistamines] exhibit pH-dependent [toxicity], highlighting the importance of considering environmental factors when evaluating the safety of these drugs.
A Shifting Desert: The Influence of pH on Antihistamine Toxicity
The study revealed that the [toxicity] of [antihistamines] is significantly affected by the pH of the environment, much like the characteristics of a desert landscape can vary greatly depending on the amount of rainfall. The authors found that [first-generation antihistamines] show increased [toxicity] at lower pH levels, whereas [second-generation antihistamines] appear to be less affected. This underscores the importance of understanding the specific properties of drugs and their interactions with the environment, especially when assessing their potential impact on aquatic life.
A New Perspective in the Desert: Understanding the Interplay of pH and Toxicity
This research provides a new perspective on the [toxicity] of [antihistamines] and its relationship to environmental factors. It's a reminder that the desert of ecotoxicology is a complex and interconnected system, where seemingly small factors can have significant consequences. By understanding the interplay of pH and [toxicity], we can develop more informed strategies for environmental protection.
Dr.Camel's Conclusion
This research is a fascinating reminder that the desert of environmental science is full of surprises. It highlights the importance of considering the complex interplay of factors, like pH, when evaluating the impact of chemicals on the environment. We must continue to explore these nuances to ensure the safety of our planet.
Date :
- Date Completed 2020-04-17
- Date Revised 2020-04-17
Further Info :
Related Literature
English
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