Achieving remission in psoriatic arthritis by early initiation of TNF inhibition: a double-blind, randomised, placebo-controlled trial of golimumab plus methotrexate versus placebo plus methotrexate.

Author: BaetenDominique, FluriInka, KokMarc, NurmohamedMichael T, de JongHenriëtte M, van KuijkArno W R, van MensLeonieke J J, van de SandeMarleen G H

Paper Details 
Original Abstract of the Article :
Early initiation of effective treatment favours remission in rheumatoid arthritis, but it remains unknown if the same concept applies to psoriatic arthritis (PsA). Therefore, this study investigated whether the combination of golimumab plus methotrexate (MTX) as a first-line treatment is superior to...See full text at original site
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引用元:
https://doi.org/10.1136/annrheumdis-2018-214746

データ提供:米国国立医学図書館(NLM)

Early TNF Inhibition: A Potential Oasis in the Desert of Psoriatic Arthritis

The [treatment of psoriatic arthritis (PsA)] is an ongoing challenge for healthcare professionals, with the goal of achieving [remission] and improving patient quality of life. This study investigates the potential of [early initiation of TNF inhibition] with [golimumab plus methotrexate (MTX)] as a first-line treatment for PsA.

The researchers conducted a double-blind, randomized, placebo-controlled trial comparing golimumab plus MTX to placebo plus MTX in patients with PsA. They found that early initiation of golimumab plus MTX was superior to MTX alone in inducing remission. This suggests that early intervention with TNF inhibitors could be a critical factor in achieving long-term remission in PsA.

A New Strategy for PsA: Early Intervention for Long-Term Benefits

The study's findings suggest that early initiation of TNF inhibition with golimumab plus MTX could significantly improve the long-term outcomes for patients with PsA, potentially leading to sustained remission and a better quality of life. It's like finding a spring of clear water in the desert of PsA, offering a potential solution for lasting relief.

Navigating the Desert of PsA: A Focus on Early Intervention

This research highlights the importance of early intervention in the treatment of PsA. By starting treatment with TNF inhibitors at the earliest possible stage, we can potentially improve the chances of achieving long-term remission and reducing the negative impact of PsA on patient lives. It's like finding a guide who can help navigate the challenging terrain of PsA, leading to a more comfortable and fulfilling journey.

Dr.Camel's Conclusion

This study is like a beacon of hope in the desert of PsA research. The findings suggest that early intervention with TNF inhibitors can be a game-changer, potentially leading to long-term remission and a better quality of life for patients with PsA. It's a reminder that early intervention can make a world of difference in the journey through chronic illness.

Date :
  1. Date Completed 2019-12-30
  2. Date Revised 2019-12-30
Further Info :

Pubmed ID

30808625

DOI: Digital Object Identifier

10.1136/annrheumdis-2018-214746

Related Literature

SNS
PICO Info
in preparation
Languages

English

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