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Effects of high-density lipoprotein targeting treatments on cardiovascular outcomes: A systematic review and meta-analysis.
Author: KaluskiEdo, KhanSafi U, LincoffA Michael, NissenSteven E, RahmanHammad, RiazHaris, ShahNishant P
Original Abstract of the Article :
BACKGROUND: The effects of increasing high-density lipoprotein cholesterol on cardiovascular outcomes remain uncertain. DESIGN: We conducted a meta-analysis to investigate the effects of high-density lipoprotein cholesterol modifiers (niacin, fibrates and cholesteryl ester transfer protein inhibito...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/30861690
データ提供:米国国立医学図書館(NLM)
The Shifting Sands of HDL Targeting Treatments: A Meta-Analysis
High-density lipoprotein (HDL), often called 'good cholesterol,' plays a crucial role in cardiovascular health. This meta-analysis examines the effects of various treatments aimed at increasing HDL levels on cardiovascular outcomes. It's like exploring a vast and complex desert, seeking to understand the intricate relationship between HDL levels and cardiovascular health.
The Quest for a Desert Oasis of Cardiovascular Health
The researchers analyzed data from 31 randomized controlled trials, encompassing a vast population of 154,601 patients. While the study found no statistically significant effect of HDL modifiers on cardiovascular mortality, stroke, or all-cause mortality, it did reveal a slight beneficial effect on myocardial infarction. It's like finding a small, hidden oasis amidst a seemingly barren landscape - a glimmer of hope, but not a complete solution.
Navigating the Uncertainties of HDL Therapy
This meta-analysis highlights the complexities of HDL therapy and the need for further research to clarify its role in preventing cardiovascular disease. It underscores the importance of a personalized approach to cardiovascular care, considering individual risk factors and tailoring treatment plans accordingly. Just as a traveler adapts to the challenges of the desert landscape, we must remain adaptable and resourceful in our approach to cardiovascular health.
Dr.Camel's Conclusion
This meta-analysis serves as a reminder that the desert of cardiovascular research is vast and complex. While the quest for a definitive solution continues, we must continue to explore new avenues and adapt our strategies based on emerging evidence. Just as a camel navigates the shifting sands, we must be prepared for the unexpected and remain open to new discoveries.
Date :
- Date Completed 2020-08-03
- Date Revised 2021-02-13
Further Info :
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English
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