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Preparation, Optimization and In vitro Evaluation of Glipizide Nanoparticles Integrated with Eudragit RS-100.

Author: BahmaniK, SaharanP, SaharanS P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Solubility is a crucial factor in drug efficacy, regardless of the administration route. However, it presents a major challenge in the pharmaceutical industry as 40% of identified active substances are insoluble or poorly soluble in aqueous media.
Paper Details　
Original Abstract of the Article :
Solubility is an important criterion for drug efficacy, independent of the route of administration. It also poses a major challenge for pharmaceutical industries, which are developing new pharmaceutical products, since 40% of the active substances being identified are either insoluble or poorly solu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691851/

データ提供：米国国立医学図書館（NLM）

A New Oasis for Solubility: Glipizide Nanoparticles Integrated with Eudragit RS-100

Solubility, like a hidden oasis in the desert of drug development, can be a key factor in determining the effectiveness of medications. This study explores a novel approach to improving the solubility of glipizide, a medication used to treat type 2 diabetes, by integrating it into nanoparticles. The authors describe a process for preparing and optimizing glipizide nanoparticles using Eudragit RS-100, a biocompatible polymer.

The authors present a detailed methodology for preparing and evaluating glipizide nanoparticles, highlighting the potential of this approach to improve drug solubility and bioavailability. This research offers a promising avenue for enhancing the effectiveness of poorly soluble drugs.

A Pathway to Improved Drug Delivery

This study highlights the potential of nanotechnology to improve drug delivery and enhance therapeutic outcomes. This research could lead to the development of more effective and efficient drug formulations for a variety of conditions.

Expanding the Horizons of Drug Delivery

This study underscores the ongoing efforts to improve drug delivery and enhance the effectiveness of medications. Nanotechnology, like a new oasis in the desert of drug development, offers promising possibilities for the future of pharmaceutical research.

Dr.Camel's Conclusion

This study explores a novel approach to improving the solubility of glipizide, a key factor in determining its effectiveness. The authors present a detailed methodology for preparing and evaluating glipizide nanoparticles, highlighting the potential of this approach to enhance drug delivery and improve therapeutic outcomes. This research represents a promising step forward in the quest to optimize drug solubility and bioavailability.

Date :
  1. Date Completed 2019-10-28
  2. Date Revised 2023-10-13
Further Info :

Pubmed ID

30892168

DOI: Digital Object Identifier

PMC6691851

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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