Side Effects of glipizide: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Main Research Findings

Glipizide, a sulfonylurea medication, has proven effective in controlling blood sugar levels in patients with type 2 diabetes who are not adequately controlled by diet alone. 28 、 22 、 29 、 18 、 19 、 30 、 27 、 25 Glipizide's mechanism involves stimulating insulin secretion from the pancreas, thereby lowering blood sugar levels. 25 This medication is often used in conjunction with diet and exercise to achieve optimal blood sugar control. 7 、 3

Reasons for Side Effects

Glipizide's primary action is to stimulate insulin secretion from the pancreas. When this process is excessive, it can lead to hypoglycemia, a condition characterized by dangerously low blood sugar levels.

Common Side Effects

Hypoglycemia

Hypoglycemia is a frequent side effect of glipizide. 28 、 22 、 29 、 19 、 30 、 27 、 6 It's more likely to occur when meals are skipped, physical activity is increased, or alcohol is consumed. 21 Symptoms of hypoglycemia include dizziness, lightheadedness, sweating, palpitations, and confusion. If you suspect hypoglycemia, immediately consume glucose or drink orange juice.

Gastrointestinal Symptoms

Glipizide can lead to gastrointestinal issues. 22 、 29 These may include nausea, vomiting, abdominal pain, and diarrhea. 7 These symptoms tend to be more prominent when you initially start taking glipizide, but often subside with continued use.

Liver Dysfunction

Although rare, glipizide can cause liver dysfunction. 27 Symptoms of liver dysfunction include jaundice, loss of appetite, and fatigue. If you suspect liver dysfunction, seek immediate medical attention.

Allergies

Glipizide can, in rare instances, trigger allergic reactions. 27 Allergic reactions may manifest as rash, itching, and difficulty breathing. If you experience these symptoms, consult your doctor immediately.

Other

Other potential side effects of glipizide, though less common, include weight gain, low platelet count, low white blood cell count, and anemia. 31 If you experience any of these, consult your doctor for advice.

Measures to Prevent Side Effects

Hypoglycemia

To minimize the risk of hypoglycemia, maintain a regular eating schedule and monitor your blood sugar levels frequently. 21 If you exercise, check your blood sugar levels before starting and consume glucose or other suitable substances as needed.

Gastrointestinal Symptoms

If gastrointestinal symptoms are bothersome, consult your doctor. Diet modification and adjusting the timing of medication administration might help alleviate these symptoms.

Liver Dysfunction

If you suspect liver dysfunction, seek immediate medical attention. Liver function tests will be performed, and treatment will be initiated if necessary.

Allergies

If you suspect an allergic reaction, consult your doctor immediately. If an allergic reaction is confirmed, glipizide administration will be stopped.

Comparison Between Studies

Commonalities

The majority of studies have demonstrated that glipizide is effective in lowering blood sugar levels. 28 、 22 、 29 、 18 、 19 、 30 、 27 、 25 Glipizide, when used in conjunction with diet and exercise, can help achieve more effective blood sugar control. 7 、 3

Differences

The frequency and types of side effects reported in studies can vary. 22 、 29 These differences might be attributed to variations in the number of study participants, their age, the severity of their diabetes, and the dosage of glipizide administered.

Cautionary Notes for Real-Life Applications

While glipizide is a valuable medication for diabetes management, it's essential to remember that it can lead to side effects like hypoglycemia. 28 、 22 、 29 Therefore, if you're taking glipizide, carefully adhere to your doctor's instructions and monitor your blood sugar levels regularly. 21 Consult your doctor before making any significant changes to your diet or exercise regimen.

Limitations of Current Research

The long-term safety of glipizide hasn't been extensively studied. Consequently, if you're taking glipizide long-term, it's crucial to consult your doctor regularly and closely monitor your overall health.

Future Research Directions

Additional research is needed to explore the long-term safety, efficacy, and side effects of glipizide. Specific areas requiring more investigation include the safety and efficacy of glipizide in elderly and renal disease patients.

Conclusion

Glipizide is a helpful medication for patients with type 2 diabetes who are not effectively controlled by diet alone. 28 、 22 、 29 、 18 、 19 、 30 、 27 、 25 However, it's important to be aware that glipizide can cause side effects like hypoglycemia. 28 、 22 、 29 If you're taking glipizide, it's essential to follow your doctor's instructions closely and monitor your blood sugar levels regularly. 21 Glipizide can be a valuable tool in managing diabetes, but it's crucial to discuss your treatment options with your doctor to determine if it's the right choice for you.

Keywords
Benefit Keywords
Dyslipidemia improvement
GLUT4 expression upregulation
T2DM dysglycemia amelioration
1
Improved blood glucose control
Reduced cardiovascular risk
3
Improved glycemic control
Low side effects
No hypoglycemia
No weight gain
Reduced cardiovascular risk
4
Hypoglycemic effect
Oral administration
5
Glycemic control
Type 2 diabetes treatment
7
Effective therapy
9
Decreased urinary calcium excretion
10
Improved glycemic control
11
Better glycaemic control
Improved quality of life
12
Hyperglycemia control
13
Diabetes management
14
Hyperglycemia control
15
Type II diabetes treatment
16
Diabetes treatment
17
Glyburide for NIDDM
Improved glycemic control
18
Long efficacy
Low side effects
Potent hypoglycemic agent
19
Decreased diabetes complications
Improved quality of life
20
Improved glycemic control
21
glycemic control
hyperglycemia reduction
22
Improved diabetes control
Safe and effective
23
Blood sugar control
24
Control blood glucose
Effective against hyperglycemia
Few side effects
25
Effective for diabetes
Increased insulin responsiveness
26
Improved blood glucose control
Well tolerated
27
Effective diabetes control
No hypoglycemia
No side effects
28
Effective blood glucose control
Well tolerated
29
Diabetes control
30
No significant side effects
Well tolerated
31
Effective for hyperglycemia
Low toxicity
32
Risk Keywords
Insolubility
2
Hypoglycemia
3
Body weight gain
Gastrointestinal complaints
Hypoglycemia
7
Gastrointestinal obstruction
8
Side effects
9
Adverse side effects
14
Hypoglycemia
16
Hypoglycemia
19
Drug interactions
Hypoglycemia
20
Hypoglycemia
21
gastrointestinal side effects
hypoglycemia
22
Side effects
24
Liver or kidney disease
25
Hypoglycemia
27
Hypoglycemia
29
Uncommon side effects
32
Literature analysis of 32 papers
Positive Content
30
Neutral Content
0
Negative Content
2
Article Type
5
0
0
12
32
4.

Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas.

Author: DeaconC F, LebovitzH E

Improved glycemic control
Low side effects
No hypoglycemia
No weight gain
Reduced cardiovascular risk

Type 2 diabetes (T2DM) is a progressive disease. Sulphonylurea drugs, a traditional second-line treatment for T2DM, can cause hypoglycemia and weight gain. Dipeptidyl peptidase (DPP)-4 inhibitors, a newer class of drugs, are equally effective in controlling blood sugar but do not cause hypoglycemia or weight gain and have fewer side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Hypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats.

Author: DasKusal K, Razzaghi-AslNima, TikareSwati N, Di SantoRoberto, CostiRoberta, MessoreAntonella, PescatoriLuca, CrucittiGiuliana Cuzzucoli, JargarJameel G, DhundasiSalim A, SasoLuciano

Hypoglycemic effect
Oral administration

A new compound, 7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione (4), has shown promise as a potential treatment for type 2 diabetes. In lab studies, this compound reduced blood sugar levels in diabetic rats by about 50% within two hours.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Use of hypoglycemic drugs during lactation.

Author: GlatsteinMiguel Marcelo, DjokanovicNada, Garcia-BournissenFacundo, FinkelsteinYaron, KorenGideon

The question concerns whether sulfonylureas, specifically glipizide, can cross into human milk and potentially affect breastfeeding infants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Antihypertensive pharmacobezoar.

Author: PrisantL Michael, SpauldingVernon C

Gastrointestinal obstruction

This article discusses the potential for gastrointestinal obstruction as a side effect of antihypertensive drugs delivered using the gastrointestinal therapeutic system. This side effect is rare but physicians should be aware of it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Practical considerations and guidelines for dosing sulfonylureas as monotherapy or combination therapy.

Author: BellDavid S H

Effective therapy
Side effects

Oral antidiabetic drugs are the first-line treatment for type 2 diabetes. Knowing the benefits and risks of each drug is important for choosing the right drug or combination for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

[Effects of octreotide on serum and urine electrolytes in a patient with parathyroid carcinoma: clinical case].

Author: YbarraJ, MoisésJ, TorregrosaJ V, MadhunZ T, SchumacherO P

Decreased urinary calcium excretion

Octreotide cannot be recommended for the treatment of parathyroid carcinoma.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

11.

Troglitazone or metformin in combination with sulfonylureas for patients with type 2 diabetes?

Author: KirkJ K, PearceK A, MichielutteR, SummersonJ H

Improved glycemic control

Troglitazone and metformin each significantly improved Hb A1c, fasting plasma glucose, and C-peptide levels when added to oral sulfonylurea therapy for patients with type 2 diabetes who had inadequate glucose control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

[Quality of life and non-insulin-dependent diabetes].

Author: TauberJ P

Better glycaemic control
Improved quality of life

Ozidia improved glycemic control and quality of life in patients with NIDDM, highlighting the potential benefits of stricter glycemic control.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

13.

Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes.

Author: AbrairaC, ColwellJ A, NuttallF Q, SawinC T, NagelN J, ComstockJ P, EmanueleN V, LevinS R, HendersonW, LeeH S

Hyperglycemia control

This study compared standard therapy and intensive therapy in a group of NIDDM men who required insulin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

14.

NIDDM in the cat: treatment with the oral hypoglycemic medication, glipizide.

Author: FordS L

Diabetes management
Adverse side effects

Glipizide effectively controlled blood sugar in approximately 50% of diabetic cats with non-insulin-dependent disease, with minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Comparison of insulin with or without continuation of oral hypoglycemic agents in the treatment of secondary failure in NIDDM patients.

Author: ChowC C, TsangL W, SorensenJ P, CockramC S

Hyperglycemia control

Insulin therapy, alone or in combination with oral hypoglycemic agents, was evaluated in patients with non-insulin-dependent diabetes mellitus. The efficacy, side effects, and quality of life were compared between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Comparison of efficacy, secondary failure rate, and complications of sulfonylureas.

Author: HarrowerA D

Type II diabetes treatment
Hypoglycemia

This review of three clinical trials compared the efficacy of different sulfonylureas in treating type II diabetes. Gliclazide demonstrated superior efficacy and a lower secondary failure rate compared to other sulfonylureas, including glibenclamide, glipizide, and gliquidone. Gliclazide also had a lower incidence of hypoglycemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Glycemic control and complications in type II diabetes. Design of a feasibility trial. VA CS Group (CSDM)

Author: AbrairaC, EmanueleN, ColwellJ, HendersonW, ComstockJ, LevinS, NuttallF, SawinC

Diabetes treatment

This study aimed to determine if an intensive treatment regimen could achieve a significant difference in HbA1c levels compared to standard therapy in type II diabetes patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

18.

Glyburide in non-insulin-dependent diabetes: an update.

Author: KoltermanO G

Glyburide for NIDDM
Improved glycemic control

Glyburide, a long-acting sulfonylurea medication, can improve glycemic control in patients with type 2 diabetes by enhancing insulin action in target tissues. It is effective in reducing fasting blood glucose and glycohemoglobin levels and may be used as adjunctive therapy to reduce insulin requirements.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM.

Author: HarrowerA D

Long efficacy
Low side effects
Potent hypoglycemic agent
Hypoglycemia

Gliclazide, a sulphonylurea, demonstrated efficacy in managing diet-failed noninsulin-dependent diabetes mellitus (NIDDM) patients. In three studies, gliclazide achieved good glycaemic control in 65% of patients, compared favorably with other sulphonylureas, and had a low incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Use of sulfonylurea agents in older diabetic patients.

Author: PetersA L, DavidsonM B

Decreased diabetes complications
Improved quality of life
Drug interactions
Hypoglycemia

Elderly patients with type II diabetes should be treated in a similar fashion to younger patients, with an emphasis on minimizing side effects, drug interactions, and hypoglycemia. Sulfonylurea agents should be started at low doses and gradually increased, and blood glucose and glycosylated hemoglobin levels should be monitored regularly to adjust therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

Antidiabetic agents.

Author: FranciscoG E

Improved glycemic control
Hypoglycemia

Insulin and oral hypoglycemics are used to manage type II diabetes, while only insulin is used for type I diabetes. C-peptide levels can be used to assess remaining pancreatic endocrine function. Intensive insulin therapy has become commonplace to control plasma glucose levels in patients receiving insulin therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

25.

Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacology, pharmacokinetics and clinical use.

Author: LebovitzH E

Control blood glucose
Effective against hyperglycemia
Few side effects
Liver or kidney disease

Glipizide is a second-generation sulfonylurea that is more effective in controlling blood sugar in patients with type 2 diabetes than first-generation sulfonylureas. While it is relatively free of serious side effects, it is contraindicated in patients with liver or kidney disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Clinical utility of oral hypoglycemic agents in the management of patients with noninsulin-dependent diabetes mellitus.

Author: LebovitzH E

Effective for diabetes
Increased insulin responsiveness

Sulfonylurea drugs are effective in controlling glycemia in patients with noninsulin-dependent diabetes mellitus. Approximately 60-70% of patients respond initially, but 15-20% do not respond initially or lose their responsiveness over time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

27.

Glipizide: an overview.

Author: ShumanC R

Improved blood glucose control
Well tolerated
Hypoglycemia

Glipizide is a safe and effective oral hypoglycemic agent for the treatment of noninsulin-dependent diabetes mellitus. It is well-tolerated, stimulates insulin action, and improves control of blood glucose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

28.

Glipizide ('Glibenese') in maturity-onset diabetes mellitus.

Author: KlaassenC H

Effective diabetes control
No hypoglycemia
No side effects

Glipizide is effective in treating diabetes. It controlled blood sugar levels in 11 newly diagnosed patients and 5 previously treated patients without causing hypoglycemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

Glipizide in the treatment of maturity-onset diabetes: a multi-centre, out-patient study.

Author: FowlerL K

Effective blood glucose control
Well tolerated
Hypoglycemia

Glipizide was effective in controlling blood glucose levels in diabetic patients. After 12 weeks, 96.7% of new patients and 90.5% of all patients were satisfactorily controlled. The drug was well-tolerated with only 4.7% of patients experiencing side effects, most of which were mild and transient hypoglycemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

30.

Clinical trial with glipizide in uncomplicated maturity onset diabetes mellitus.

Author: AmanM, JawadF, SultanaS, Waiz-ul-Haq, NanjiR

Diabetes control

Glipizide was effective in controlling blood sugar levels in non-insulin dependent diabetic patients and was well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

31.

An evaluation of the effects of some sulphonylureas on platelet function.

Author: KingJ B, KalkW J, VinikA I, JacksonW P, BracherM, JacobsP

No significant side effects
Well tolerated

Gliclazide and glibenese did not produce any additional effect on platelet function in maturity-onset diabetic subjects. They were well tolerated and had no significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

32.

Clinical evaluation of a new sulfonylurea in maturity onset diabetes - glipizide (K-4024).

Author: BandisodeM S, BoshellB R

Effective for hyperglycemia
Low toxicity
Uncommon side effects

Glipizide, a new low dose sulfonylurea, was found to be effective in controlling hyperglycemia in diabetic patients, with low toxicity and few side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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