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Adapalene-loaded poly(ε-caprolactone) microparticles: Physicochemical characterization and in vitro penetration by photoacoustic spectroscopy.

Author: BarbozaFernanda Malaquias, DiasDaniele Toniolo, Dos Anjos CamargoGuilherme, FaragoPaulo Vitor, LyraAmanda, MacenhanWilliam Roger, NadalJessica Mendes, NovatskiAndressa, Padilha de PaulaJosiane, RoikJoão Ricardo, SomerAloisi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adapalene is a retinoid used to treat acne topically, but its commercial formulation can cause side effects. This study investigated the encapsulation of adapalene in PCL microparticles to circumvent these side effects. The microparticles showed high encapsulation efficiency and reduced in vitro transmembrane diffusion of adapalene, suggesting potential for improved topical delivery.
Paper Details　
Original Abstract of the Article :
Adapalene (ADAP) is an important drug widely used in the topical treatment of acne. It is a third-generation retinoid and provides keratolytic, anti-inflammatory, and antiseborrhoic action. However, some topical adverse effects such as erythema, dryness, and scaling have been reported with its comme...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428289/

データ提供：米国国立医学図書館（NLM）

Adapalene Microparticles: A Journey Through the Desert of Acne

Acne, like a stubborn desert weed, can be a persistent and frustrating skin condition. This study, like an expedition across a desolate landscape, explores the potential of adapalene-loaded poly(ε-caprolactone) microparticles as a novel treatment for acne. The researchers, like intrepid explorers, sought to improve the delivery and efficacy of adapalene, a widely used retinoid, by encapsulating it within microparticles. This innovative approach aims to overcome the limitations of traditional topical formulations and deliver a more targeted and effective treatment.

Microencapsulation: A Desert Oasis of Delivery

The study, like a meticulous craftsman carving a delicate sculpture from sand, meticulously characterized the microparticles, focusing on their morphology, spectroscopy, and thermal properties. They found that the microparticles effectively encapsulated adapalene, achieving an encapsulation efficiency of over 98%. Furthermore, the microencapsulation process seemed to reduce the in vitro transmembrane diffusion of adapalene, suggesting that it could potentially enhance the drug's effectiveness by prolonging its release and reducing its absorption into the surrounding skin.

Navigating the Desert of Acne: A New Path to Clear Skin

The study, like a guiding star in the desert, holds promising implications for the treatment of acne. The researchers' innovative approach to delivering adapalene through microparticles could potentially lead to more effective and targeted acne treatments. However, further research is necessary to validate these findings in clinical trials and evaluate the long-term safety and efficacy of this novel approach.

Dr. Camel's Conclusion

Microencapsulation, like a resourceful camel storing water in its hump, has the potential to revolutionize the treatment of acne. This study offers a glimpse into a promising future for tackling this common skin condition.
Date :
  1. Date Completed 2019-12-26
  2. Date Revised 2020-03-09
Further Info :

Pubmed ID

30897170

DOI: Digital Object Identifier

PMC6428289

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SNS
PICO Info
in preparation
Languages

English

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