Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome.

Author: BaranovPavel V, FirthAndrew E, KefiAmira, KlepackiDorota, MankinAlexander S, MargusTōnu, MarksJames, MeydanSezen, SharmaVirag, Vázquez-LaslopNora

Paper Details 
Original Abstract of the Article :
The use of alternative translation initiation sites enables production of more than one protein from a single gene, thereby expanding the cellular proteome. Although several such examples have been serendipitously found in bacteria, genome-wide mapping of alternative translation start sites has been...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/30904393

データ提供:米国国立医学図書館(NLM)

Unlocking the Secrets of the Bacterial Proteome: Retapamulin-Assisted Ribosome Profiling

The bacterial proteome, the complete set of proteins produced by a bacterium, is vast and complex. It's like a bustling desert marketplace, teeming with diverse goods and services. This research explores the use of [retapamulin] to map the bacterial proteome, revealing the presence of [alternative translation initiation sites] in the bacterial genome. It's like a desert guide using a special lens to uncover hidden pathways and treasures in the vast expanse of the desert.

The study found that retapamulin, an antibiotic that targets bacterial ribosomes, can be used to identify alternative translation initiation sites. This is like a skilled desert explorer using a magnifying glass to identify different types of desert plants and animals, uncovering hidden aspects of the ecosystem. The researchers discovered that these alternative initiation sites can lead to the production of a wider variety of proteins than previously thought, expanding the bacterial proteome.

Expanding the Proteome: Retapamulin-Assisted Ribosome Profiling

This research presents a novel approach for mapping the bacterial proteome, utilizing retapamulin to identify alternative translation initiation sites. It's like a desert nomad uncovering new and hidden oases, expanding our understanding of the desert's rich and diverse ecosystem. The findings offer a new perspective on bacterial protein synthesis, revealing the complexity and adaptability of these organisms.

Understanding Bacteria: A Deeper Dive into Their World

This study provides valuable insight into the intricate mechanisms of bacterial protein synthesis. It's like a camel caravan embarking on a journey through the desert, uncovering the secrets of this fascinating and complex landscape. The findings enhance our understanding of bacterial biology, contributing to the development of new and effective strategies for controlling bacterial infections.

Dr. Camel's Conclusion

This research explores the use of retapamulin-assisted ribosome profiling to reveal the alternative bacterial proteome. It's like a desert nomad using a special lens to uncover hidden pathways and treasures in the vast expanse of the desert. The findings offer a new perspective on bacterial protein synthesis, revealing the complexity and adaptability of these organisms.

Date :
  1. Date Completed 2019-10-22
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

30904393

DOI: Digital Object Identifier

EMS93391

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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