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The ameliorative effects of ceftriaxone and vitamin E against cisplatin-induced nephrotoxicity.

Author: Abdel-DaimMohamed M, AbushoukAbdelrahman Ibrahim, Al-SultanNouf K, AlBasherGadah, AlahmariAbeer, AlarifiSaud, AleyaLotfi, AlghamdiJawahir, AliDaoud, AlkahtaneAbdullah A, AlkahtaniSaad, AlmeerRafa S, BungauSimona G, El-BialyBadr E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cisplatin (CDDP) can cause kidney damage (nephrotoxicity). This study found that ceftriaxone (CTX) and vitamin E (Vit.E), especially when combined, can reduce CDDP-induced kidney injury. This protection is likely due to their antioxidant and anti-inflammatory effects.
Paper Details　
Original Abstract of the Article :
Nephrotoxicity is a common adverse effect of treatment with cisplatin (CDDP). This study was performed to evaluate the antioxidant and nephroprotective efficacy of ceftriaxone (CTX) and vitamin E (Vit.E), alone and in combination against CDDP-induced acute renal injury. Fifty-six male albino rats we...See full text at original site
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引用元：
https://doi.org/10.1007/s11356-019-04801-2

データ提供：米国国立医学図書館（NLM）

Combating Cisplatin-Induced Nephrotoxicity: The Protective Effects of Ceftriaxone and Vitamin E

Cisplatin (CDDP), a powerful chemotherapy drug, is often used to treat various cancers. However, its effectiveness is often hampered by its nephrotoxic side effects, which can damage the kidneys. This study examines the protective effects of ceftriaxone (CTX) and vitamin E (Vit.E) against CDDP-induced acute renal injury in rats. The researchers found that both CTX and Vit.E, administered alone or in combination, significantly ameliorated the nephrotoxic effects of CDDP, as evidenced by reduced levels of renal injury biomarkers and improved antioxidant enzyme activity. The study highlights the potential of CTX and Vit.E as protective agents against CDDP-induced nephrotoxicity.

Ceftriaxone and Vitamin E: A Protective Shield Against Kidney Damage

This research suggests that CTX and Vit.E, both readily available medications, could play a crucial role in protecting against the damaging effects of CDDP on the kidneys. The study's findings could lead to new strategies for minimizing nephrotoxicity and improving the safety of CDDP-based chemotherapy regimens.

Protecting Our Kidneys: A Vital Consideration During Chemotherapy

The study emphasizes the importance of protecting kidney health during chemotherapy treatment. By understanding the protective effects of CTX and Vit.E, healthcare professionals can work to mitigate the risks of CDDP-induced nephrotoxicity and improve the overall health and well-being of cancer patients.

Dr. Camel's Conclusion

Just as a camel can survive in harsh desert environments, researchers are constantly searching for ways to mitigate the side effects of cancer treatment. This study highlights the potential of ceftriaxone and vitamin E to protect against cisplatin-induced nephrotoxicity, offering a promising approach to enhancing the safety and effectiveness of chemotherapy.

Date :
  1. Date Completed 2019-07-11
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30929167

DOI: Digital Object Identifier

10.1007/s11356-019-04801-2

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Languages

English

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