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Comparative neuropsychological effects of carbamazepine and eslicarbazepine acetate.

Author: BoydAlan, Falco-WalterJessica, LeScheherazade, LoringDavid W, MeadorKimford J, RazaviBabak, SeligerJordan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Eslicarbazepine acetate (ESL) showed less adverse neuropsychological effects compared to carbamazepine (CBZ) in a randomized crossover study in healthy volunteers. ESL was particularly beneficial for executive function and selective attention, suggesting it might be a more neuropsychologically well-tolerated antiseizure medication.
Paper Details　
Original Abstract of the Article :
People with epilepsy are at increased risk for neuropsychological dysfunction due to multiple factors, of which the most amendable are antiseizure medications (ASMs). Antiseizure medication effectiveness is frequently determined by tolerability. In this study, we compared the neuropsychological effe...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2019.02.034

データ提供：米国国立医学図書館（NLM）

Epilepsy Medications: Comparing the Neuropsychological Effects of Carbamazepine and Eslicarbazepine Acetate

Epilepsy is a neurological disorder that affects millions worldwide, and antiseizure medications (ASMs) play a crucial role in managing the condition. However, some ASMs can have unwanted neuropsychological side effects. This study compared the neuropsychological effects of eslicarbazepine acetate (ESL) and carbamazepine (CBZ) in healthy volunteers. The researchers found that ESL had fewer adverse neuropsychological effects compared to CBZ, suggesting that ESL may be a better tolerated option for patients with epilepsy. This study provides valuable information for clinicians in selecting the most appropriate ASM for individual patients.

Eslicarbazepine Acetate: A Potentially Safer Option for Epilepsy

The study found that ESL had fewer adverse neuropsychological effects compared to CBZ, particularly on executive function and selective attention. This suggests that ESL may be a better tolerated option for patients with epilepsy, especially those who are concerned about potential neuropsychological side effects of their medication. These findings highlight the importance of considering the individual needs of patients and choosing the ASM that best balances efficacy and tolerability.

Living Well With Epilepsy: Minimizing Neuropsychological Side Effects

Epilepsy can have a significant impact on a patient's quality of life. This research underscores the importance of minimizing neuropsychological side effects associated with ASM treatment. The findings highlight the potential of ESL as a safer option, allowing patients to manage their epilepsy effectively while minimizing the negative impact on their cognitive function and overall well-being.

Dr.Camel's Conclusion

This study delves into the neuropsychological effects of two antiseizure medications, offering valuable insights for clinicians in selecting the best treatment option for their patients. The study emphasizes the importance of considering individual patient needs and balancing efficacy with tolerability. As Dr. Camel, I am always fascinated by the intricate workings of the brain and the impact of various treatments on cognitive function. This research reinforces my belief that finding the right solution for each individual is essential for maximizing well-being and promoting a high quality of life.

Date :
  1. Date Completed 2020-06-29
  2. Date Revised 2020-06-29
Further Info :

Pubmed ID

30939410

DOI: Digital Object Identifier

10.1016/j.yebeh.2019.02.034

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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