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Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin.

Author: ArnoldCarolyn, DowellSamantha, ScottErin M, SuchodolskiJan S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The ocular surface microbiome of healthy horses was stable over time and after topical antibiotic treatment. The most abundant phyla were Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. This study provides insights into the equine ocular surface microbiome and its response to antibiotic therapy.
Paper Details　
Original Abstract of the Article :
Next generation sequencing (NGS) studies have demonstrated a rich and diverse ocular surface-associated microbiota in people that was previously undetected by traditional culture-based methods. The ocular surface microbiome of horses has yet to be investigated using NGS techniques. This study aimed ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447178/

データ提供：米国国立医学図書館（NLM）

Exploring the Ocular Surface Microbiome in Horses: A Microbial Oasis

Imagine the ocular surface of a horse’s eye as a miniature desert oasis, a haven for a diverse community of microbes. This study, like an intrepid explorer, delves into the microbial landscape of the equine ocular surface, using next-generation sequencing (NGS) to uncover its secrets. Their objective? To identify the bacterial composition of the ocular surface microbiome in healthy horses and see how it changes over time and after topical antibiotic treatment.

A Stable Microbial Ecosystem

The study found a stable and diverse microbial community on the equine ocular surface, dominated by Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes. These microbes co-exist in a delicate balance, forming a crucial part of the horse's immune system. It's like a thriving ecosystem within a desert oasis, with each microbe playing a vital role in maintaining balance.

Antibiotic Treatment: A Minor Disturbance in the Oasis

The researchers treated one eye of 12 horses with topical neomycin-polymyxin-bacitracin ophthalmic ointment. The treatment, while effective in controlling bacterial infections, had only a minimal impact on the overall diversity and composition of the ocular surface microbiome. This is a positive finding, suggesting that the equine ocular surface is resilient, like a desert oasis that can withstand occasional droughts.

Dr.Camel's Conclusion

This study provides valuable insights into the microbial landscape of the equine ocular surface. It reveals a stable and diverse community, highlighting the importance of this microbiome for equine health. The study also demonstrates that topical antibiotics can be used effectively without significantly disrupting this delicate microbial balance. It’s like a desert oasis that can withstand occasional disturbances, maintaining its vibrant ecosystem.

Date :
  1. Date Completed 2019-12-26
  2. Date Revised 2020-03-09
Further Info :

Pubmed ID

30943258

DOI: Digital Object Identifier

PMC6447178

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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