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Antileishmanial activity of H1-antihistamine drugs and cellular alterations in Leishmania (L.) infantum.
Author: TemponeAndre Gustavo, Treiger BorboremaSamanta Etel, de Melo MendesViviane
Original Abstract of the Article :
Leishmaniases are infectious diseases caused by protozoan parasites Leishmania and transmitted by sand flies. Drug repurposing is a therapeutic approach that has shown satisfactory results in their treatment. Analyses of antihistaminic drugs have revealed their in vitro and in vivo activity against ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.actatropica.2019.04.017
データ提供：米国国立医学図書館（NLM）
H1-Antihistamines: Exploring New Frontiers in Antileishmanial Therapy
The pursuit of effective antileishmanial therapies is a journey through a vast and complex landscape, like traversing a scorching desert. This research, like a determined explorer, delves into the potential of H1-antihistamines, a class of drugs commonly used to treat allergies, as antileishmanial agents. The authors investigate the activity of various H1-antihistamines against Leishmania (L.) infantum, a parasitic protozoan that causes leishmaniasis. Their findings suggest that certain H1-antihistamines may offer promising therapeutic potential for this neglected tropical disease.
H1-Antihistamines: A Potential New Weapon Against Leishmaniasis
This research, like a skilled archer aiming for a target, explores the potential of H1-antihistamines as antileishmanial agents. The authors find that certain H1-antihistamines demonstrate significant activity against both promastigotes and amastigotes of L. infantum, highlighting their potential as a novel therapeutic approach for this debilitating disease. This study, like a well-placed oasis in a parched desert, offers a ray of hope for the development of new antileishmanial therapies.
A Promising Avenue for Drug Repurposing
This research, like a guide leading us through uncharted territory, opens new avenues for drug repurposing. The authors' findings suggest that existing H1-antihistamines may offer a promising therapeutic approach for leishmaniasis. This study underscores the potential of repurposing existing drugs to combat neglected tropical diseases, offering a cost-effective and efficient approach to addressing global health challenges.
Dr.Camel's Conclusion
This study offers compelling evidence for the potential of H1-antihistamines as antileishmanial agents. The findings suggest that certain H1-antihistamines demonstrate significant activity against L. infantum, highlighting their potential as a novel therapeutic approach. This research, like a beacon of hope in a vast and unforgiving desert, provides a promising avenue for drug repurposing and the development of new therapies for this neglected tropical disease.
Date :
- Date Completed 2019-08-07
- Date Revised 2019-08-07
Further Info :
Related Literature
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