Effects of meclizine: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Meclizine has been shown to have a variety of effects in a number of studies. In the nervous system, meclizine has shown neuroprotective effects and has been shown to reduce pain from chemotherapy-induced neuropathy. 8 Meclizine is thought to be effective in treating balance disorders by regulating the release of neurotransmitters. 19 Meclizine has been shown to be effective in reducing nausea and vomiting caused by chemotherapy. 15 Furthermore, meclizine has also been shown to prevent cognitive decline by suppressing brain inflammation. 17

Meclizine also has effects on bone metabolism and may be useful in the prevention and treatment of osteoporosis. 23 Meclizine has been shown to reduce the symptoms of muscular dystrophy and increase muscle strength. 11 Meclizine may improve heart function and help prevent and treat heart disease. 20 Meclizine has the potential to be effective in the treatment of viral infections. 12 , 10 Furthermore, meclizine is expected to reduce space sickness in astronauts. 2

Benefits and Risks

Benefits Summary

Meclizine is thought to be effective in suppressing nausea and vomiting, neuroprotection, treating balance disorders, improving cognitive function, preventing and treating osteoporosis, reducing the symptoms of muscular dystrophy, improving heart function, treating viral infections, and reducing space sickness.

Risks Summary

Side effects of meclizine include drowsiness, dry mouth, constipation, and vision abnormalities. 3 Meclizine should be taken only after consulting a doctor if you are pregnant or breastfeeding. Meclizine is more likely to cause side effects in older adults. Meclizine may interact with other medications, so if you are taking other medications, consult your doctor before taking meclizine.

Comparison Between Studies

Commonalities Between Studies

Multiple studies have confirmed that meclizine shows neuroprotective effects, suppresses nausea and vomiting, improves bone metabolism, and improves muscle function.

Differences Between Studies

The effects of meclizine have been shown to vary depending on the disease, dosage, and administration method. For example, in terms of neuroprotective effects, meclizine has been shown to be effective in reducing pain from chemotherapy-induced neuropathy, 8 but no effect was observed in suppressing the death of nerve cells due to spinal cord injury. 14 While meclizine is expected to be effective in the prevention and treatment of osteoporosis, 23 it is not effective in all bone diseases.

Consistency and Contradictions in the Results

Meclizine has been reported to have a variety of effects, but its mechanism of action is not fully understood. Also, because the effects of meclizine vary depending on the disease, dosage, and administration method, it is not possible to say definitively which diseases it is effective in treating. Further research is needed to clarify the effects of meclizine.

Cautions Regarding Application to Real Life

While meclizine is expected to be effective for a variety of diseases, it is important to consider the risks of side effects. Consult a doctor before taking meclizine and follow the appropriate dosage and administration instructions.

Current Limitations of the Research

Research on meclizine is still insufficient. Further research is needed to clarify the effects of meclizine. In particular, elucidating the mechanism of action of meclizine is crucial in finding more effective ways to use it and reduce side effects.

Future Research Directions

Future research on meclizine should aim to elucidate its mechanism of action and clarify its effects. Research into methods for reducing the side effects of meclizine is also needed.

Conclusion

Meclizine is thought to be effective in suppressing nausea and vomiting, neuroprotection, treating balance disorders, improving cognitive function, improving bone metabolism, improving muscle function, improving heart function, treating viral infections, and reducing space sickness. Consult a doctor before taking meclizine and follow the appropriate dosage and administration instructions.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
0
Negative Content
3
Article Type
0
0
0
0
27
1.

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

Author: HarrisonDavid E, StrongRandy, ReifsnyderPeter, RosenthalNadia, KorstanjeRon, FernandezElizabeth, FlurkeyKevin, GinsburgBrett C, MurrellMeredith D, JavorsMartin A, Lopez-CruzanMarisa, NelsonJames F, WillcoxBradley J, AllsoppRichard, WatumullDavid M, WatumullDavid G, CortopassiGino, KirklandJames L, TchkoniaTamar, ChoiYoung Geun, YousefzadehMatthew J, RobbinsPaul D, MitchellJames R, AcarMurat, SarnoskiEthan A, BeneMichael R, SalmonAdam, KumarNavasuja, MillerRichard A

Extended lifespan

This study investigated the effects of astaxanthin (Asta), an Nrf2 activator, and meclizine (Mec), an mTORC1 inhibitor, on lifespan in genetically heterogeneous (UM-HET3) mice. Asta and Mec extended median male lifespan by 12% and 8%, respectively.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes.

Author: LiuJuli, WuShiyong, ZhangYucheng, WangCheng, LiuSheng, WanJun, YangLei

COVID-19 complications
Cardiomyocyte damage

This study elucidates the deleterious effects of SARS-CoV-2 genes Nsp6, M, and Nsp8 on human cardiomyocytes (CMs), contributing to a better understanding of the virus's impact on cardiovascular health and its role in COVID-19 mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles.

Author: Tucker EdmisterSara, Del Rosario HernándezThaís, IbrahimRahma, BrownCameron A, GoreSayali V, KakodkarRohit, KreilingJill A, CretonRobbert

Alzheimer's disease prevention

This study screened a small-molecule library of FDA-approved drugs for effects on behavior in zebrafish larvae. The study identified a cluster of drugs including calcineurin inhibitors, which may have potential for the prevention and treatment of Alzheimer's disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes.

Author: LiuJuli, ZhangYucheng, HanLei, GuoShuai, WuShiyong, DoudEmma Helen, WangCheng, ChenHanying, Rubart-von der LoheMichael, WanJun, YangLei

Cardiac abnormalities
Cardiac injury

This study investigated the detrimental effects of the SARS-CoV-2 gene Orf9c on human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). Orf9c overexpression led to apoptosis, electrical dysfunctions, and reduced ATP levels. The study also explored potential therapeutic approaches using FDA-approved drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice.

Author: KawamuraYusuke, HidaTetsuro, OhkawaraBisei, MatsushitaMasaki, KobayashiTakeshi, IshizukaShinya, HiraiwaHideki, TanakaSatoshi, TsushimaMikito, NakashimaHiroaki, ItoKenyu, ImagamaShiro, ItoMikako, MasudaAkio, IshiguroNaoki, OhnoKinji

Muscle function improvement

Meclozine, an antihistamine drug commonly used for motion sickness, has been found to promote the proliferation and survival of human myogenic progenitors (Hu5/KD3 cells). The study showed that meclozine increased MyoD expression while reducing myosin heavy chain expression, suggesting it may promote myogenesis but inhibit myotube formation. The study also investigated the effects of meclozine in mdx mice, a model for Duchenne muscular dystrophy, and found that meclozine increased muscle mass, improved exercise performance, and decreased ERK1/2 phosphorylation in mdx mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Meclizine Inhibits Pseudorabies Virus Replication by Interfering With Virus Entry and Release.

Author: LiuPanrao, HuDanhe, YuanLili, LianZhengmin, YaoXiaohui, ZhuZhenbang, NowotnyNorbert, ShiYi, LiXiangdong

PRV treatment

This study investigates the antiviral effects of meclizine against pseudorabies virus (PRV), finding that it inhibits viral entry, cell-to-cell spreading, and particle release, and reduces the severity of PRV infection in mice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

A new dual function orodissolvable/dispersible meclizine HCL tablet to challenge patient inconvenience: in vitro evaluation and in vivo assessment in human volunteers.

Author: DarweshAlaa Y, El-DahhanMarwa S, MeshaliMahasen M

Enhanced convenience
Prolonged drug absorption
Rapid drug absorption

A dual function tablet containing nanoparticles of MCZ from chitosan (CS) and shellac (SH) was prepared for rapid and prolonged drug absorption. The tablet disintegrated in 58 s at pH 5.5, achieving both rapid and prolonged absorption in humans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and "cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats.

Author: GaoLiansheng, WangChun, QinBing, LiTao, XuWeilin, LenahanCameron, YingGuangyu, LiJianru, ZhaoTengfei, ZhuYongjian, ChenGao

Neuroprotection

This study investigated the neuroprotective role of PFKFB3 in traumatic spinal cord injury (t-SCI). PFKFB3 activation by meclizine significantly enhanced glycolysis, attenuated t-SCI-induced spinal cord injury, and alleviated neurological impairment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy.

Author: GuanYuan, ChenXinyu, WuManhong, ZhuWan, ArslanAhmed, TakedaSaori, NguyenMindie H, MajetiRavindra, ThomasDan, ZhengMing, PeltzGary

Liver development study

This study examined the early stages of hepatic organoid formation from human induced pluripotent stem cells (iPSCs). The goal was to identify key pathways affecting early liver development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Effect of the novel histamine H<sub>4</sub> receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss.

Author: PetremannMathieu, GueguenCindy, Delgado BetancourtViviana, WersingerEric, Dyhrfjeld-JohnsenJonas

Vertigo improvement

This study investigated the effects of SENS-111, a drug that blocks histamine H4 receptors, in rats with a unilateral vestibular lesion (damage to one side of the inner ear). The study found that SENS-111 improved vertigo symptoms in the rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The effect of anti-emetic drugs on rat embryonic heart activity.

Author: RitchieHelen E, HussIsabelle Broström, WebsterWilliam S

NVP treatment
Birth defects
Bradycardia

This study investigated the effects of antiemetic medications on the heart rate of rat embryos. All of the medications tested caused bradycardia, with droperidol having the lowest margin of safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake.

Author: AlbercaLucas N, SbaragliniMaría L, MoralesJuan F, DietrichRoque, RuizMaría D, Pino MartínezAgustina M, MirandaCristian G, FraccaroliLaura, Alba SotoCatalina D, CarrilloCarolina, PalestroPablo H, TaleviAlan

Chagas disease treatment

Cinnarizine, a drug frequently prescribed for motion sickness, was found to be effective against *Trypanosoma cruzi* epimastigotes and amastigotes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR.

Author: GuoJiachao, LiWeijin, WuYingxing, JingXingzhi, HuangJunming, ZhangJiaming, XiangWei, RenRanyue, LvZhengtao, XiaoJun, GuoFengjing

Bone loss prevention
Osteoclastogenesis inhibition

Meclizine, an agonist of the pregnane X receptor (PXR), inhibits osteoclastogenesis by regulating several RANKL signaling pathways. This suggests that meclizine may be a novel therapeutic candidate for osteoclast-related diseases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia.

Author: MatsushitaMasaki, EsakiRyusaku, MishimaKenichi, IshiguroNaoki, OhnoKinji, KitohHiroshi

Achondroplasia treatment
Bone growth stimulation
Bone volume improvement
Toxicity

Meclozine, an anti-motion sickness drug, was effective in rescuing short-limbed phenotype in a mouse model of achondroplasia (ACH) by suppressing FGFR3 signaling. Repeated administration of meclozine at 2 mg/kg/day was safe and well-tolerated, suggesting potential for clinical application in ACH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Transdermal Scopolamine Withdrawal Syndrome Case Report in the Pediatric Cerebral Palsy Population.

Author: ChowdhuryNasim A, SewatskyMary Laura, KimHeakyung

Botulinum toxin efficacy
Sialorrhea treatment
Scopolamine withdrawal

This case report describes a 15-year-old boy with cerebral palsy (CP) who experienced scopolamine withdrawal after receiving botulinum toxin A injections for sialorrhea. The authors emphasize the importance of recognizing and promptly treating scopolamine withdrawal syndrome, which can lead to complications if not addressed.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia.

Author: MatsushitaMasaki, MishimaKenichi, EsakiRyusaku, IshiguroNaoki, OhnoKinji, KitohHiroshi

Bone growth promotion

Meclozine is a medication used to treat motion sickness. This study investigated the effects of maternal meclozine administration on foramen magnum stenosis in mice with achondroplasia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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