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N-Methyl-d-aspartate receptor open-channel blockers memantine and magnesium modulate nociceptive trigeminovascular neurotransmission in rats.

Author: GoadsbyPeter J, HoffmannJan, ParkJeong-Wook, StorerRobin James

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effectiveness of Mg<sup>2+</sup> and memantine, low-affinity N-methyl-d-aspartate (NMDA) receptor open-channel blockers, in reducing trigeminal nociceptive activation in an in vivo model. The study found that local application of Mg<sup>2+</sup> or memantine effectively inhibited trigeminal activation, while intravenous administration did not, suggesting that further exploration of these channel blockers as a therapeutic strategy for primary head pain is warranted.
Paper Details　
Original Abstract of the Article :
Experimental and clinical studies suggest that the low-affinity N-methyl-d-aspartate (NMDA) receptor open-channel blockers Mg<sup>2+</sup> and memantine are effective in reducing trigeminal nociceptive activation. The aim of this study was to investigate the apparent effectiveness of these channel b...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31009120

データ提供：米国国立医学図書館（NLM）

Memantine and Magnesium: Potential Headache Relief Through NMDA Receptor Modulation

Headaches, particularly migraines, are a common and often debilitating condition. This study investigated the potential of memantine and magnesium, NMDA receptor open-channel blockers, in reducing trigeminal nociceptive activation, a key mechanism involved in headache pain. The researchers conducted experiments to assess the effects of these drugs on trigeminal nerve activity in rats.

Memantine and Magnesium: Effective in Reducing Trigeminal Nociceptive Activation

The study found that both memantine and magnesium effectively inhibited mechanically and electrically stimulated craniovascular afferents, suggesting their potential to reduce headache pain. However, the effects were only observed when these drugs were applied locally. Systemic administration of memantine and magnesium did not significantly affect trigeminal nerve activity. The study highlights the need for further research to explore alternative delivery methods or investigate other NMDA receptor modulators for effective headache treatment.

Targeting NMDA Receptors: A New Approach to Headache Management

This study provides evidence for the potential of NMDA receptor modulation as a novel approach to headache treatment. While memantine and magnesium showed promising results in reducing trigeminal nociceptive activation, further research is needed to develop effective delivery methods for these drugs or explore other NMDA receptor modulators to optimize their therapeutic potential in treating headaches.

Dr. Camel's Conclusion

This research provides valuable insights into the potential of memantine and magnesium, NMDA receptor open-channel blockers, in reducing headache pain. While the study demonstrated effectiveness when these drugs were applied locally, further research is needed to develop effective delivery methods or explore other NMDA receptor modulators for optimal therapeutic efficacy. It opens new avenues for exploring innovative approaches to managing headaches and alleviating pain for those suffering from this common condition.

Date :
  1. Date Completed 2020-08-10
  2. Date Revised 2022-10-05
Further Info :

Pubmed ID

31009120

DOI: Digital Object Identifier

EMS128034

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