Effects of naratriptan: A Synthesis of Findings from 26 Studies

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Original Abstract of the Article

Main Research Findings

Naratriptan is a medication that is used to treat migraines. Research has shown that naratriptan can be effective in treating migraine attacks, including those that are related to menstruation. 11 indicated that naratriptan appears to be particularly beneficial for treating migraines associated with menstruation. Additionally, naratriptan has been found to be effective in reducing nausea and vomiting, common symptoms associated with migraines. 4 revealed that naratriptan is an effective treatment for menstrually related migraine (MRM). The study found that a higher percentage of subjects in the naratriptan group experienced complete pain relief compared to the placebo group. Furthermore, a significant difference in favor of naratriptan was observed for various aspects such as sustained pain-free response, absence of associated symptoms, and patient satisfaction. 1 explored the potential of naratriptan in treating spinal and bulbar muscular atrophy (SBMA), a motor neuron disease caused by an expanded polyglutamine repeat tract. The study discovered that naratriptan, a serotonin 1B/1D (5-HT1B/1D) receptor agonist, mitigated the neurotoxic effects of pathogenic AR by decreasing CGRP1 expression and attenuating JNK activity. These findings suggest that naratriptan might offer therapeutic benefits for SBMA and other polyglutamine-related neurodegenerative diseases. However, it is important to note that naratriptan can also cause side effects, including chest pain. 3 found that naratriptan, along with other triptans, induced vasoconstriction in the thoracic blood vessels of a significant portion of patients. This vasoconstriction may explain why some patients experience chest symptoms as a side effect of migraine treatment with triptans.

Benefits and Risks

Benefits Summary

Naratriptan is an effective treatment for migraines, including those associated with menstruation. It can also help reduce nausea and vomiting, common symptoms of migraines. Additionally, naratriptan has shown potential for treating certain neurodegenerative diseases, such as spinal and bulbar muscular atrophy (SBMA). This makes it a valuable tool for managing various conditions related to migraines and neurological disorders.

Risks Summary

Naratriptan can cause side effects, including chest pain. It is generally not recommended for patients with pre-existing heart conditions. While chest pain is a potential risk for all triptans, it is crucial to monitor and address this symptom if it occurs after taking naratriptan.

Comparison Across Studies

Similarities Across Studies

Multiple studies have consistently demonstrated the efficacy of naratriptan in treating migraine attacks, including those related to menstruation. These studies also highlight the potential of naratriptan for managing nausea and vomiting associated with migraines. However, the risk of chest pain as a side effect has been consistently reported across different studies.

Differences Across Studies

The findings regarding naratriptan’s effectiveness and side effects may vary depending on the specific patient population, treatment approaches, and research methods employed in each study. This highlights the need for further research to gain a more comprehensive understanding of naratriptan’s impact on different individuals and its long-term effects.

Consistency and Contradictions in Results

The majority of studies consistently demonstrate the effectiveness of naratriptan in treating migraines, particularly those linked to menstruation. However, some research findings contradict each other regarding the safety of naratriptan for individuals with pre-existing heart conditions. Further investigation is needed to clarify the potential risks and benefits of naratriptan for this specific patient population.

Considerations for Real-World Application

Naratriptan can be an effective treatment option for migraines. However, it is essential to consult with a physician to determine the appropriate dosage and treatment approach based on individual needs and health conditions. It is crucial to be aware of the potential side effects, such as chest pain, and seek medical attention if any concerning symptoms occur. Individuals with heart conditions should discuss the risks and benefits of naratriptan with their healthcare provider before using this medication.

Limitations of Current Research

The existing research on naratriptan’s effectiveness and safety is limited by factors such as varying patient populations, treatment approaches, and research methods. These limitations emphasize the need for more comprehensive and standardized research to provide a more definitive understanding of naratriptan’s impact on different individuals.

Future Research Directions

Future research should focus on exploring the long-term effects of naratriptan on patients with various health conditions, particularly those with pre-existing heart conditions. Additional studies are necessary to understand the specific mechanisms by which naratriptan interacts with the body and to develop more targeted treatments for specific migraine subtypes.

Conclusion

Naratriptan is a valuable treatment option for migraines, especially those related to menstruation. It has shown promise in reducing nausea and vomiting associated with migraines. However, potential side effects, particularly chest pain, must be considered. Individuals with heart conditions should exercise caution and consult their healthcare provider before using naratriptan. Further research is needed to better understand the long-term effects of naratriptan on various patient populations, allowing for more precise and personalized treatment approaches.

Literature analysis of 26 papers
Positive Content
24
Neutral Content
1
Negative Content
1
Article Type
1
2
1
10
26
1.

Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract.

Author: MinamiyamaMakoto, KatsunoMasahisa, AdachiHiroaki, DoiHideki, KondoNaohide, IidaMadoka, IshigakiShinsuke, FujiokaYusuke, MatsumotoShinjiro, MiyazakiYu, TanakaFumiaki, KuriharaHiroki, SobueGen

Neurodegeneration prevention
SBMA treatment

This study investigated the role of calcitonin gene-related peptide α (CGRP1) in spinal and bulbar muscular atrophy (SBMA). The results showed that pathogenic androgen receptor (AR) upregulates CGRP1 expression, which contributes to neuronal damage. Pharmacological suppression of CGRP1 or the c-Jun N-terminal kinase (JNK) pathway attenuated the neurotoxic effects of pathogenic AR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Transformed migraine and medication overuse in a tertiary headache centre--clinical characteristics and treatment outcomes.

Author: BigalM E, RapoportA M, SheftellF D, TepperS J, LiptonR B

Headache relief
Migraine improvement
Medication overuse

This study examines the patterns of analgesic overuse in patients with transformed migraine and the outcomes of medication detoxification. The results demonstrate a significant improvement in headache frequency, duration, and overall score in patients who successfully discontinued medication overuse.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Triptans induce vasoconstriction of human arteries and veins from the thoracic wall.

Author: WackenforsAngelica, JarviusMalin, IngemanssonRichard, EdvinssonLars, MalmsjöMalin

Migraine treatment
Chest symptoms

Chest symptoms are a common side effect of triptans. The study found that triptans cause vasoconstriction in the thoracic blood vessels of 38% to 57% of patients, likely through activation of 5-HT1B receptors. This could explain why a similar number of patients experience chest symptoms as a side effect of migraine treatment with triptans.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Efficacy of oral naratriptan in the treatment of menstrually related migraine.

Author: MassiouH, JaminC, HinzelinG, Bidaut-MazelC,

Associated symptom control
MRM pain relief
Sustained pain relief
Work ability
Adverse events

Oral naratriptan (2.5 mg) was effective in the acute treatment of menstrually related migraine, with significant pain relief observed as early as 2 hours after treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The pathophysiological and pharmacological basis of current drug treatment of migraine headache.

Author: ReddyDoodipala Samba

Migraine treatment

This article reviews the current treatment options for migraine, including over-the-counter analgesics, triptans, ergot alkaloids, and prophylactic agents. It highlights the need for new drugs with improved efficacy and reduced side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics.

Author: MatthaeiJ, KuronD, FaltracoF, KnochT, Dos Santos PereiraJ N, Abu AbedM, PrukopT, BrockmöllerJ, TzvetkovM V

Improved sumatriptan bioavailability

Sumatriptan, an anti-migraine drug, has low bioavailability due to hepatic metabolism. This study investigated the impact of the organic cation transporter OCT1 on sumatriptan uptake and pharmacokinetics. OCT1 polymorphisms can significantly reduce sumatriptan uptake and increase plasma concentrations, highlighting the importance of genetic factors in drug response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.

Author: MarmuraMichael J, SilbersteinStephen D, SchwedtTodd J

Migraine treatment
Opioid use

This review provides an updated assessment of the evidence for pharmacological therapies used to treat acute migraine attacks. The study focused on medications available from 1998 to 2013 and evaluated their effectiveness based on the level of evidence. Triptans and dihydroergotamine are effective (Level A). Ergotamine and other forms of dihydroergotamine are likely effective (Level B). Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, sumatriptan/naproxen, and acetaminophen/aspirin/caffeine are effective nonspecific medications (Level A). Ketoprofen, intravenous and intramuscular ketorolac, flurbiprofen, intravenous magnesium, and the combination of isometheptene compounds, codeine/acetaminophen, and tramadol/acetaminophen are likely effective (Level B). Antiemetics prochlorperazine, droperidol, chlorpromazine, and metoclopramide are also likely effective (Level B). While opioids like butorphanol, codeine/acetaminophen, and tramadol/acetaminophen are probably effective, they are not recommended for regular use due to their potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Naratriptan in the preventive treatment of refractory transformed migraine: a prospective pilot study.

Author: SheftellFred D, RapoportAlan M, TepperStewart J, BigalMarcelo E

Reduce headache frequency
Reduce rescue medication use

Daily naratriptan was found to be effective in preventing transformed migraine in patients refractory to other treatments. The treatment was well tolerated with no serious adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

The safety of sumatriptan and naratriptan in pregnancy: what have we learned?

Author: CunningtonMarianne, EphrossSara, ChurchillPaige

Major birth defects

The risk of all major birth defects following first-trimester exposure to sumatriptan was 4.6%. This coupled with a consistent failure of additional epidemiological studies to observe a signal for major teratogenicity gives a level of reassurance concerning the safety of sumatriptan in pregnancy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

10.

Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches.

Author: RobertClaude, BourgeaisLaurence, ArretoCharles-Daniel, Condes-LaraMiguel, NosedaRodrigo, JayThérèse, VillanuevaLuis

Paraventricular hypothalamic neurons directly control the activity of medullary trigeminovascular neurons in rats. This suggests that these neurons could be involved in the modulation or triggering of migraine and trigeminal autonomic cephalalgias.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Naratriptan is as effective as sumatriptan for the treatment of migraine attacks when used properly. A mini-review.

Author: Tfelt-HansenPeer

Fast onset
Migraine relief
Side effects

Naratriptan, marketed in a low oral dose (2.5 mg), was less effective than sumatriptan. Oral naratriptan 10 mg had similar efficacy to sumatriptan 100 mg. Subcutaneous naratriptan 10 mg showed the greatest effect of any triptan.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.

Author: VieiraDomingos Sávio deSouza, Naffah-MazzacorattiMaria da Graça, ZukermanEliova, Senne SoaresCarlos Augusto, CavalheiroEsper Abräo, PeresMario Fernando Prieto

Glutamate may play a role in triptan response mechanisms for acute migraine treatment. Its involvement in central sensitization, which can impact triptan effectiveness, suggests a potential connection between glutamate and migraine chronification.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Triptans and gastric accommodation: pharmacological and therapeutic aspects.

Author: MoroE, CremaF, De PontiF, FrigoG

Dyspepsia treatment
Gastric accommodation improvement

This review discusses the potential of sumatriptan, a 5-HT1B/D receptor agonist, in treating functional dyspepsia by improving gastric accommodation and reducing epigastric symptoms. The review highlights the potential therapeutic role of 5-HT1B/D receptor agonists in functional dyspepsia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Using patient-centered endpoints to determine the cost-effectiveness of triptans for acute migraine therapy.

Author: KelmanLeslie, Von SeggernRandal L

Cost-effectiveness
Migraine treatment
Adverse events

This study compares the cost-effectiveness of six oral triptans for treating acute migraine headaches. Almotriptan 12.5 mg was found to be the most cost-effective option, providing the highest sustained pain-free rate with the lowest adverse event rate compared to other triptans.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Use of existing electronic health care databases to evaluate medication safety in pregnancy: Triptan exposure in pregnancy as a case study.

Author: YusufAkeem, ChiaVictoria, XueFei, MikolDaniel D, BollingerLisa, CangialoseCharles

Pregnancy safety

Electronic health records may be used to gather safety data on medications during pregnancy, potentially replacing traditional pregnancy registries.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Preclinical neuropharmacology of naratriptan.

Author: LambertGeoffrey A

Treats Migraine
Treats Migraine Nausea
Serotonin Syndrome

This review discusses the basic CNS neuropharmacology of naratriptan, a second-generation triptan antimigraine drug. Naratriptan has a highly selective action on migraine pain and nausea, without significant effect on other pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Triptan exposure during pregnancy and the risk of major congenital malformations and adverse pregnancy outcomes: results from the Norwegian Mother and Child Cohort Study.

Author: Nezvalová-HenriksenKaterina, SpigsetOlav, NordengHedvig

Atonic uterus
Hemorrhage

Triptan therapy during pregnancy was not associated with an overall increased risk of congenital malformations. However, there was a slight increase in the risk of atonic uterus and hemorrhage associated with triptan use during the second and/or third trimesters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Triptans and troponin: a case report.

Author: WederClaudia R, SchneemannMarkus

Acute coronary syndrome

This case report describes the first instance of acute coronary syndrome occurring in a patient after taking naratriptan, a medication used to treat migraine. The case highlights the potential for triptans to cause acute coronary syndromes, even in patients without pre-existing heart disease.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Temporary confusion depending on the usage of naratriptan.

Author: KutluhanSuleyman, IncekaraFidan, SozenAyse, KoyuncuogluHasan Rifat, TakRukiye, GokalpOsman, GultekinFatih

migraine treatment
vitamin B12 deficiency

This report describes a case of a patient with vitamin B12 deficiency who experienced temporary confusion when taking naratriptan for migraine attacks.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Naproxen with or without an antiemetic for acute migraine headaches in adults.

Author: LawSimon, DerrySheena, MooreR Andrew

Reduced migraine
Nausea
Vomiting

Naproxen, an NSAID, may be effective for acute migraine headaches, especially when combined with an antiemetic to reduce nausea and vomiting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

The use of triptans for pediatric migraines.

Author: EilandLea S, HuntMelissa O

Migraine treatment
Triptan side effects

This review discusses the use of triptans in children and adolescents with migraines, highlighting the available data on efficacy and safety, and recommending specific triptans based on the current evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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