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Effects of 1 gram oral or intravenous aspirin on urinary excretion of thromboxane B2 and 6-keto-PGF1 alpha in healthy subjects.

Author: BodzentaA, BucchiF, CerlettiC, de GaetanoG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Aspirin was administered orally and intravenously to 6 healthy subjects to compare its effects on platelet and renal prostanoids. Both routes suppressed platelet cyclooxygenase activity, but only intravenous aspirin significantly reduced urinary excretion of TxB2 and 6-keto-PGF1 alpha.
Paper Details　
Original Abstract of the Article :
Aspirin inhibits cyclo-oxygenase, thus preventing prostanoids formation. After oral administration aspirin is hydrolysed to inactive salicylate partly within the gastrointestinal tract, partly during first pass in the liver, partly in the circulation by plasma esterases. Intravenous aspirin, in cont...See full text at original site
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引用元：
https://doi.org/10.1016/0090-6980(86)90191-7

データ提供：米国国立医学図書館（NLM）

Aspirin: Exploring the Impact on Urinary Prostanoids

Aspirin, a common medication used for pain relief and fever reduction, is like a reliable camel in the desert of medicine. This study investigates the impact of aspirin, administered orally and intravenously, on urinary excretion of thromboxane B2 and 6-keto-PGF1 alpha in healthy subjects. The researchers found that while both routes of administration effectively suppressed platelet cyclo-oxygenase activity, only intravenous aspirin significantly reduced urinary excretion of these prostanoids. This research provides valuable insights into the differential effects of aspirin depending on its route of administration, highlighting the importance of understanding the nuances of drug delivery in achieving desired therapeutic outcomes.

Aspirin: A Case for Understanding Drug Delivery

This study highlights the importance of understanding drug delivery mechanisms and their impact on therapeutic outcomes. It demonstrates that the route of administration can influence the effectiveness of aspirin in modulating prostanoid levels. These findings emphasize the need for careful consideration of drug delivery strategies to optimize therapeutic effects.

Navigating the Desert of Drug Delivery

The desert of drug delivery is vast and complex, with different routes of administration leading to unique outcomes. This study reminds us of the importance of understanding the intricacies of drug delivery mechanisms to ensure optimal therapeutic effects. It’s a reminder that the journey towards healing requires a thorough understanding of the tools we utilize.

Dr.Camel's Conclusion

This study is like a journey across a desert, where the choice of path can significantly impact the outcome. Just as a camel follows a specific route to find water, the route of administration can influence the impact of aspirin on prostanoid levels. This research underscores the importance of understanding the intricacies of drug delivery to ensure optimal therapeutic effects in the vast and complex desert of medicine.

Date :
  1. Date Completed 1987-04-20
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

3103169

DOI: Digital Object Identifier

10.1016/0090-6980(86)90191-7

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Languages

English

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