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Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014.

Author: BrombergJonathan S, DorganJoanne F, EngelsEric A, LynchCharles F, MagderLaurence S, MorrisCyllene R, NooneAnne-Michelle, PawlishKaren S, PfeifferRuth M

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Cancer is a substantial cause of mortality among solid organ transplant recipients, with major contributions reported from lung cancer and NHL. Cancer-attributable mortality increases with age and time since transplantation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Solid organ transplant recipients have an elevated risk of cancer. Quantifying deaths attributable to cancer can inform priorities to reduce cancer burden. METHODS: Linked transplantation and cancer registry data were used to identify incident cancers and deaths among solid organ transp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31034602

データ提供：米国国立医学図書館（NLM）

Cancer's Shadow: A Growing Threat for Transplant Recipients

Organ transplantation is a life-saving procedure that offers a second chance for individuals with organ failure. However, transplant recipients face an increased risk of developing cancer. This research investigates the burden of cancer-related mortality among solid organ transplant recipients in the United States from 1987 to 2014. The study aimed to quantify the number of deaths attributable to cancer in this population and identify the most common types of cancer contributing to mortality.

A Complex Legacy: The Price of Survival

The study found that cancer contributed to approximately 13% of deaths among solid organ transplant recipients. Lung cancer, non-Hodgkin lymphoma, colorectal cancer, and kidney cancer were among the leading causes of cancer-related mortality. The study also revealed that cancer-attributable mortality increased with age at transplantation and time since transplantation.

Managing Cancer Risk in Transplant Recipients

This study emphasizes the importance of proactive cancer surveillance and prevention strategies for transplant recipients. Early detection and timely treatment are crucial for improving cancer outcomes in this vulnerable population. This is crucial because the results from this study suggest that cancer is a significant cause of death in this population, and therefore careful management of cancer risk is essential to improve the health and longevity of transplant recipients.

Dr. Camel's Conclusion

Imagine a camel caravan crossing a vast desert, leaving a trail in its wake. Just as a caravan's journey leaves a trace on the desert landscape, organ transplantation leaves a complex legacy for recipients, including an increased risk of developing cancer. This research, like a map highlighting potential dangers in the desert, underscores the importance of vigilant cancer screening and prevention strategies for transplant recipients.

Date :
  1. Date Completed 2020-05-12
  2. Date Revised 2023-12-10
Further Info :

Pubmed ID

31034602

DOI: Digital Object Identifier

NIHMS1020601

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English

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