Causes of kidney cancer: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Key research findings

There are various factors that may contribute to the development of kidney cancer. Based on the research data, factors that may increase the risk of kidney cancer include weight cycling, genetic mutations, exposure to asbestos, high blood pressure, and chronic kidney disease. 3 , , ,

Reasons for causes

The causes of kidney cancer are thought to be complex, involving a combination of genetic, environmental, and lifestyle factors. , ,

Common causes

Weight cycling

Weight cycling may affect the risk of kidney cancer, but a direct causal link between weight gain and kidney cancer is unclear. 3

Genetic mutations

Genetic mutations can significantly contribute to the development of kidney cancer. Specifically, mutations in the VHL gene are known to increase the risk of kidney cancer. , ,

Exposure to asbestos

Exposure to asbestos may increase the risk of kidney cancer.

High blood pressure

High blood pressure may increase the risk of kidney cancer.

Chronic kidney disease

Chronic kidney disease may increase the risk of kidney cancer.

Measures for causes

Weight management

Maintaining a healthy weight and avoiding weight fluctuations is essential. 3

Genetic testing

If there is a family history of kidney cancer, genetic testing may be considered. ,

Avoidance of exposure to asbestos

It is important to avoid exposure to asbestos.

Management of high blood pressure

High blood pressure can be managed with proper treatment.

Management of chronic kidney disease

Chronic kidney disease can be managed with proper treatment.

Comparison across studies

Commonalities among studies

Many studies have identified genetic mutations, high blood pressure, and chronic kidney disease as common factors that increase the risk of kidney cancer. , , ,

Differences among studies

The relationship between weight cycling and the risk of kidney cancer has not been consistently demonstrated across all studies. 3

Caveats for application in daily life

These research findings suggest factors that may increase the risk of kidney cancer, but they cannot predict individual risk. It is important to consult a doctor about your risk of kidney cancer and prevention strategies.

Limitations of current research

Research on the causes of kidney cancer is still not complete. In particular, more research is needed on environmental and lifestyle factors. Additionally, further research is needed to clarify how genetic mutations contribute to the development of kidney cancer.

Future research directions

Further research is needed to understand the mechanisms of kidney cancer development and to develop effective prevention and treatment methods. It is especially important to clarify how complex factors, such as environmental and lifestyle factors, genetic mutations, epigenetics, and others, contribute to the development of kidney cancer.

Conclusion

Various factors contribute to the development of kidney cancer. Genetic mutations, high blood pressure, and chronic kidney disease have been suggested to increase the risk of kidney cancer. It is important to maintain a healthy lifestyle and undergo regular health check-ups.

Literature analysis of 7 papers
Positive Content
2
Neutral Content
1
Negative Content
4
Article Type
0
1
1
1
7
1.

Pharmacokinetic considerations for therapies used to treat interstitial cystitis.

Author: GardellaBarbara, PorruDaniele, AllegriMassimo, BoglioloStefano, IacoboneAnna Daniela, MinellaCristina, NappiRossella Elena, FerreroSimone, SpinilloArsenio

IC/BPS treatment

Interstitial cystitis (IC), also called bladder pain syndrome (BPS), causes pain above the pubic bone that worsens with a full bladder. It's characterized by frequent urination, urgency, and pain, but the cause is unknown. Currently, there are no long-term effective treatments for IC/BPS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Comorbidities and causes of death in the management of localized T1a kidney cancer.

Author: PatelHiten D, KatesMax, PierorazioPhillip M, GorinMichael A, JayramGautam, BallMark W, HyamsElias S, AllafMohamad Ezzeddine

Prognostic aid
Decreased survival

Congestive heart failure, chronic kidney disease, peripheral vascular disease, chronic obstructive pulmonary disease, diabetes, and cerebrovascular disease were associated with decreased overall survival among Medicare beneficiaries with small renal masses. A simplified cardiovascular index could serve as a clinically useful prognostic aid for older patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

3.

Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies.

Author: LeeDong Hoon, KeumNaNa, RezendeLeandro F M, TabungFred K, HongSungEun, GiovannucciEdward L

Increased kidney cancer

Frequent substantial weight cycling was associated with an increased risk of kidney cancer, independent of BMI. The pooled multivariable-adjusted hazard ratio for severe cyclers compared to non-cyclers was 1.78 (95% CI, 1.19, 2.66).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.

Author: DeutschmeyerVerena, BreuerJanina, WaleschSara K, SokolAnna M, GraumannJohannes, BartkuhnMarek, BoettgerThomas, RossbachOliver, RichterAntje M

Epigenetic therapy
ZAR1 biomarker

Zygote arrest 1 (ZAR1) is a novel cancer biomarker for lung and kidney cancers, which is epigenetically silenced by DNA hypermethylation. Epigenetic therapy can reactivate the ZAR1 tumor suppressor in cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Cancer-attributable mortality among solid organ transplant recipients in the United States: 1987 through 2014.

Author: NooneAnne-Michelle, PfeifferRuth M, DorganJoanne F, MagderLaurence S, BrombergJonathan S, LynchCharles F, MorrisCyllene R, PawlishKaren S, EngelsEric A

Increased cancer risk

Cancer is a substantial cause of mortality among solid organ transplant recipients, with major contributions reported from lung cancer and NHL. Cancer-attributable mortality increases with age and time since transplantation.

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Kidney cancer trends and risk factors in Lebanon: a 12-year epidemiological study.

Author: AssouadElise, El HageSaid, SafiSteven, El KarehAntonio, MokledElie, SalamehPascale

Kidney cancer

Lebanon presented an average-to-high age-standardized rate (ASR) for kidney cancer compared to regional countries but a below-average ASR compared to countries worldwide. The rising kidney cancer trends highlight the need for preventive and screening measures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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