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[Assessment of the efficacy and tolerance of a benzodiazepine antagonist (Ro 15-1788)].

Author: ForsterA, GemperleM, RouillerM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ro 15-1788, a benzodiazepine antagonist, was tested for its ability to reverse the effects of midazolam in 6 healthy volunteers. Ro 15-1788 was successful in reversing the effects of midazolam, including dysarthria, cessation of counting, and loss of the ciliary reflex.
Paper Details　
Original Abstract of the Article :
The aim of this study was to evaluate the efficacy and the tolerance of Ro 15-1788, a specific benzodiazepine antagonist, in reversing the effects of midazolam. Six healthy male volunteers (mean age 32 +/- 3 years; mean weight 75.5 +/- 5 kg) took part in this study. Two of the three following drugs:...See full text at original site
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引用元：
https://doi.org/10.1016/S0750-7658(87)80001-1

データ提供：米国国立医学図書館（NLM）

Ro 15-1788: Reversing the Effects of Benzodiazepines

This research explores the efficacy and tolerability of Ro 15-1788, a specific benzodiazepine antagonist, in reversing the effects of midazolam, a benzodiazepine drug used for sedation. The study involved six healthy male volunteers who received intravenous injections of midazolam, Ro 15-1788, or placebo in a double-blind manner. The results indicate that Ro 15-1788 effectively reversed the effects of midazolam, including sedation, dysarthria (slurred speech), and amnesia. The study highlights the potential of Ro 15-1788 as an antidote for benzodiazepine overdose.

Antidotal Effects: A Lifeline in Benzodiazepine Overdose

This study demonstrates the potential of Ro 15-1788 to reverse the effects of benzodiazepine overdose. It's like finding a hidden oasis in the desert of benzodiazepine toxicity – a source of relief and restoration. The study's findings highlight the importance of having effective antidotes available for managing potential drug overdoses, ensuring the safety and well-being of individuals.

Navigating the Desert of Drug Overdose: The Importance of Antidotes

Drug overdose is a serious public health concern, and having effective antidotes is crucial for mitigating potential harm. This study underscores the importance of research and development in this area. It's like preparing for a desert journey – having essential supplies and tools is vital for navigating the journey safely. The study's findings encourage further research into the development of effective antidotes for various drug overdoses, potentially saving lives and reducing the burden of this public health issue.

Dr.Camel's Conclusion

This research highlights the importance of developing effective antidotes for drug overdoses. It's a reminder that even in the face of unforeseen challenges, we can rely on medical advancements to provide solutions and protect lives. Just as the desert offers both beauty and danger, the world of medicine is constantly evolving, offering hope and resilience in the face of adversity.

Date :
  1. Date Completed 1987-05-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3107442

DOI: Digital Object Identifier

10.1016/S0750-7658(87)80001-1

SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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