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[Clinical and hemodynamic effects of nisoldipine and captopril in heart failure: a double-blind comparative study of long and short-term effects].

Author: FigullaH R, KreuzerH, LuigH, NieschlagF

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This double-blind study compared the effects of nisoldipine (a calcium antagonist) and captopril (an ACE inhibitor) in patients with heart failure. Nisoldipine showed an initial increase in LVEF, but this effect disappeared after 3 months.
Paper Details　
Original Abstract of the Article :
Afterload reduction with angiotensin-converting enzyme inhibitors (ACE-inhibitors), such as captopril, is an established therapeutic measure in the adjunctive treatment of severe chronic heart failure. Unfortunately, several side effects and adverse reactions are related to this form of therapy. Cal...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3109142

データ提供：米国国立医学図書館（NLM）

Nisoldipine and Captopril: A Tale of Two Heart Failure Treatments

Chronic heart failure is a complex condition, much like the ever-changing sands of the desert. It requires careful management and effective treatment strategies. This double-blind study explores the effects of two medications, nisoldipine (a calcium antagonist) and captopril (an ACE inhibitor), in the treatment of heart failure. The researchers compared the acute and chronic hemodynamic and clinical benefits of these two drugs in patients with severe heart failure.

Nisoldipine: A Short-Term Benefit in Heart Failure Management

The results showed that nisoldipine led to a significant increase in left ventricular ejection fraction (LVEF) within the first 3 days of treatment. However, this improvement disappeared after 3 months. While nisoldipine showed a short-term benefit, captopril demonstrated sustained improvement in hemodynamic parameters. This suggests that captopril may be a more effective long-term treatment for heart failure. However, the study's limited sample size warrants further research to confirm these observations.

Choosing the Right Path in Heart Failure Treatment

This study highlights the importance of considering the long-term effects of medications in managing chronic conditions like heart failure. While nisoldipine shows promise for short-term improvement, captopril appears to offer a more sustained benefit. The choice of treatment should be based on individual patient needs and medical history, carefully considering the potential benefits and risks of each medication. Consulting with a qualified healthcare professional is crucial for making informed decisions about heart failure treatment.

Dr.Camel's Conclusion

This study offers a valuable comparison of nisoldipine and captopril in heart failure treatment. While both medications offer benefits, captopril appears to provide more sustained improvement in hemodynamic parameters. The choice of medication should be personalized based on individual patient needs and medical history. This research provides a foundation for further investigation into the long-term effects of these medications in heart failure management.

Date :
  1. Date Completed 1987-06-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3109142

DOI: Digital Object Identifier

3109142

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Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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