Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor.

Author: AbateCarmen, ChiangChi-Shiun, LiHsueh-Yin, LinChiu-Min, LiuChia-Chi, WangHsia-Han, WangShu-Chi, YuChing-Fang

Paper Details 
Original Abstract of the Article :
There are limited effective drugs that can reach the brain to target brain tumors, in particular glioblastoma, which is one of the most difficult cancers to be cured from. Because the overexpression of the sigma-2 receptor is frequently reported in glioma clinical samples and associated with poor pr...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528305/

データ提供:米国国立医学図書館(NLM)

Sigma-2 Receptor: A Potential Target for Brain Tumor Treatment

The quest for effective treatments for brain tumors, particularly glioblastoma, is a formidable challenge in the field of [oncology]. This study explores the potential of targeting the sigma-2 receptor as a therapeutic strategy for brain cancer. The researchers investigated the anti-tumor effects of PB221, a sigma-2 receptor agonist, on an anaplastic astrocytoma tumor model. They found that PB221 exhibited anti-tumor activity, suggesting that targeting the sigma-2 receptor could be a viable approach for treating brain tumors. This study offers promising insights into a potential new avenue for tackling this challenging cancer.

Targeting the Sigma-2 Receptor: A Potential Breakthrough in Brain Tumor Treatment

This study's findings provide a glimmer of hope for patients battling brain tumors. The discovery that PB221, a sigma-2 receptor agonist, demonstrates anti-tumor activity against anaplastic astrocytoma cells suggests a potential new therapeutic approach for this aggressive cancer. While further research is needed, this study highlights the importance of exploring novel targets and therapies in the fight against brain tumors.

Navigating the Labyrinth of Brain Cancer Treatment

Imagine navigating a labyrinthine desert, seeking a path to conquer a formidable foe. Glioblastoma, a particularly aggressive brain tumor, is a formidable challenge. This study suggests that targeting the sigma-2 receptor, like finding a hidden passage within the labyrinth, could potentially lead to new and effective therapies for brain cancer.

Dr. Camel's Conclusion

As a researcher who has traversed the vast desert of cancer research, I'm always on the lookout for innovative approaches to combat this devastating disease. This study on the potential of targeting the sigma-2 receptor for brain tumor treatment is a testament to the ongoing pursuit of new and effective therapies. The researchers' findings, showing the anti-tumor activity of PB221, offer a glimmer of hope for a future where we can more effectively combat this challenging cancer. This study serves as a reminder that continued research and exploration of new targets are essential in the fight against brain tumors.

Date :
  1. Date Completed 2019-12-23
  2. Date Revised 2021-02-19
Further Info :

Pubmed ID

31109310

DOI: Digital Object Identifier

PMC6528305

Related Literature

SNS
PICO Info
in preparation
Languages

English

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