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A Systematic Review of the Role of Definitive Local Treatment in Patients with Clinically Lymph Node-positive Prostate Cancer.

Author: AbdollahFiras, BrigantiAlberto, ChenRonald C, ChengLiang, FonteyneValerie, JamesNicholas, RoachMack, SeisenThomas, ThalmannGeorge N, TouijerKarim, VentimigliaEugenio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Local treatment (LT), including radical prostatectomy or radiotherapy, was associated with an advantage in terms of overall survival (OS) and cancer-specific survival (CSS) compared to androgen deprivation therapy (ADT) alone in men with clinically lymph node-positive (cN+) prostate cancer. A systematic review of 5 nonrandomized studies suggested that LT may provide a survival benefit, although these results should be interpreted with caution due to the low level of evidence.
Paper Details　
Original Abstract of the Article :
CONTEXT: There is uncertainty regarding the oncologic effectiveness and the survival advantage of local treatment (LT) in men with clinically lymph node-positive (cN+) prostate cancer (PCa). OBJECTIVE: To systematically review the current literature comparing oncologic outcomes associated with the ...See full text at original site
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引用元：
https://doi.org/10.1016/j.euo.2019.02.001

データ提供：米国国立医学図書館（NLM）

The Role of Definitive Local Treatment in Clinically Lymph Node-Positive Prostate Cancer

Prostate cancer is a prevalent disease, and the choice of treatment strategy is crucial for achieving optimal outcomes. This research investigates the role of definitive local treatment (LT) in men with clinically lymph node-positive (cN+) prostate cancer. The study systematically reviews the available literature, comparing the oncologic outcomes of LT combined with androgen deprivation therapy (ADT) versus ADT alone. The researchers examine the impact of LT on recurrence-free survival, cancer-specific survival (CSS), and overall survival (OS) in cN+ prostate cancer patients.

The Potential Benefits of Definitive Local Treatment in Clinically Lymph Node-Positive Prostate Cancer

The study suggests that the use of LT, including both radical prostatectomy (RP) and radiotherapy (RT), is associated with improved OS and CSS compared to ADT alone in men with cN+ prostate cancer. While the review highlights the potential benefits of LT, it emphasizes the need for caution due to the low level of evidence available. The researchers call for further research to provide stronger evidence supporting the role of LT in cN+ prostate cancer.

Navigating Treatment for Clinically Lymph Node-Positive Prostate Cancer

Men with cN+ prostate cancer should consult with their healthcare providers to discuss the risks and benefits of different treatment options, including LT. The decision should be made on a case-by-case basis, considering the individual patient's stage of cancer, overall health, and preferences. It's like navigating a vast desert, carefully choosing the right path to ensure optimal outcomes.

Dr. Camel's Conclusion

This research sheds light on the evolving understanding of treatment strategies for cN+ prostate cancer. The study highlights the potential benefits of LT, but also underscores the need for further research to provide stronger evidence. It emphasizes the importance of collaborative decision-making between patients and healthcare providers to ensure the most effective and personalized approach to treatment.

Date :
  1. Date Completed 2020-06-02
  2. Date Revised 2021-03-17
Further Info :

Pubmed ID

31200844

DOI: Digital Object Identifier

10.1016/j.euo.2019.02.001

Related Literature

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・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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