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Prevention of postsurgical lymphedema via immediate delivery of sustained-release 9-cis retinoic acid to the lymphedenectomy site.

Author: CooperMichael N, DaneshgaranGiulia, HongYoung-Kwon, JiaoWan, KimGene H, LoAndrea, PaikConnie B, ParkSun Young, SungCynthia, WongAlex K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explores the potential of a single-use depot drug delivery system for delivering 9-cis retinoic acid (9-cis RA) to the site of lymphatic injury. The aim is to determine if this approach can effectively mitigate the development of lymphedema.
Paper Details　
Original Abstract of the Article :
Previously, we have shown that 9-cis retinoic acid (9-cis RA) stimulates lymphangiogenesis and limits postsurgical lymphedema in animal models when administered via daily intraperitoneal injections. In this study, we investigate whether a single-use depot 9-cis RA drug delivery system (DDS) implante...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31240729

データ提供：米国国立医学図書館（NLM）

A New Approach to Preventing Lymphedema

This study delves into the [innovative field of lymphedema prevention] using [sustained-release 9-cis retinoic acid (9-cis RA)] delivered directly to the [lymphadenectomy site]. The research explores the potential of this approach in mitigating [postsurgical lymphedema] in a [clinically relevant mouse limb model]. This research sheds light on the promising potential of this novel drug delivery system for improving lymphedema management.

Sustained-Release 9-cis RA: A Potential Game-Changer

This study demonstrates the potential of a single-use depot 9-cis RA drug delivery system in preventing postsurgical lymphedema. The research suggests that this approach could be a promising alternative to traditional treatments for lymphedema, potentially offering a more effective and convenient way to manage this condition. The study highlights the importance of further research to evaluate the effectiveness and safety of this system in humans.

Navigating the Labyrinth of Lymphatics: A Journey of Discovery

This study offers hope for individuals facing lymphedema. It reminds us that the desert of lymphatic health can be a complex and challenging landscape. By exploring innovative approaches to treatment and prevention, we can find new ways to navigate these challenging conditions and achieve a better quality of life. It's important to work closely with your doctor to understand your individual needs and potential treatment options.

Dr.Camel's Conclusion

This study, "Prevention of postsurgical lymphedema via immediate delivery of sustained-release 9-cis retinoic acid to the lymphedenectomy site," investigated the potential of a sustained-release 9-cis RA drug delivery system in preventing postsurgical lymphedema. The study demonstrates the promising potential of this approach in mitigating lymphedema development, suggesting a potential new avenue for lymphedema management.

Date :
  1. Date Completed 2020-01-23
  2. Date Revised 2021-01-01
Further Info :

Pubmed ID

31240729

DOI: Digital Object Identifier

NIHMS1034428

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Languages

English

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