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Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT.

Author: AmblerGareth, BartonKeith, BunceCatey, BuszewiczMarta, GargAnurag, Garway-HeathDavid, GazzardGus, HunterRachael, KonstantakopoulouEvgenia, MorrisStephen, NathwaniNeil, RubinGary, VickerstaffVictoria, WormaldRichard

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A 36-month randomized controlled trial comparing selective laser trabeculoplasty (SLT) to topical IOP-lowering medication as first-line treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) found that SLT provided stable, drop-free IOP control in 74.2% of patients for at least 3 years, with reduced surgery, lower cost, and comparable health-related quality of life.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Newly diagnosed open-angle glaucoma (OAG) and ocular hypertension (OHT) are habitually treated with intraocular pressure (IOP)-lowering eyedrops. Selective laser trabeculoplasty (SLT) is a safe alternative to drops and is rarely used as first-line treatment. OBJECTIVES: To compare healt...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627009/

データ提供：米国国立医学図書館（NLM）

SLT Versus Eyedrops: A Head-to-Head Comparison for Ocular Hypertension and Glaucoma

The field of [ophthalmology] is constantly searching for the best ways to manage [ocular hypertension (OHT) and open-angle glaucoma (OAG)]. This study compares the effectiveness and cost-effectiveness of two treatment pathways: [topical IOP-lowering medication (Medicine-1st)] versus [selective laser trabeculoplasty (SLT) followed by topical medications as needed (Laser-1st)]. The researchers conducted a [36-month randomized controlled trial] to assess the long-term impact of these two approaches on health-related quality of life (HRQoL), clinical outcomes, and costs.

SLT: A Cost-Effective and Stable Treatment Option

The study found that [SLT provided stable, drop-free IOP control] for a significant proportion of patients for at least 3 years. This led to a [reduced need for surgery] and [lower overall costs] compared to medication-based treatment. Importantly, SLT did not have a negative impact on HRQoL. The researchers concluded that SLT appears to be the [most cost-effective first-line treatment option] for OAG and OHT.

A Promising Future for SLT

This study provides strong evidence supporting the use of [SLT as a first-line treatment] for OAG and OHT. The researchers encourage [further longitudinal research] to investigate the long-term effects of SLT on disease progression, treatment intensity, and surgery rates. Their findings suggest that SLT may be a valuable tool for managing these conditions, potentially improving both clinical outcomes and cost-effectiveness.

Dr.Camel's Conclusion

Ocular hypertension and glaucoma can be challenging conditions to manage, but SLT offers a promising alternative to traditional medication-based treatment. This study reveals that SLT provides stable IOP control, reduces the need for surgery, and is cost-effective. Like a camel using its keen eyesight to navigate the desert landscape, clinicians are working to find innovative and effective ways to protect vision and preserve eye health.

Date :
  1. Date Completed 2020-10-01
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31264958

DOI: Digital Object Identifier

PMC6627009

Related Literature

Article Analysis
・Effective treatment of glaucoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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