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Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

Author: AbelLaurent, BelkayaSerkan, BossuytXavier, BoudewijnsRobbert, BucciolGiorgia, CasanovaJean-Laurent, Changi-AshtianiMajid, CobatAurelie, DrutmanScott, EnemchukwuChibuzo, GijsbersRik, GoudourisEkaterini, HernandezNicholas, HertzogPaul, HoffmannHans-Heinrich, HommaAkira, JochmansDirk, JouanguyEmmanuelle, JuradoAndrea, Le PenJérémie, Lefevre-UtileAlain, Lorenzo-DiazLazaro, MacDonaldMargaret R, MaiaMaria de Lourdes S, MarrNico, MartinsReinaldo de Menezes, MesquitaEmersom Ciclini, MeytsIsabelle, MoensLeen, MomenilandiMana, NeytsJohan, PholienRuben, PöyhönenLaura, ReisliIsmail, RiceCharles M, Rokni-ZadehHassan, SayarEsra Hazar, SeeleuthnerYoann, SeligmanStephen J, ShahrooeiMohammad, ShirkaniAfshin, SiqueiraMarilda M, TietjenIan, ZhangQian, ZhangShen-Ying, ZijlmansDick, da Costa BarrosTamiris Azamor, de LimaSheila M Barbosa, de OliveiraPatricia Mouta Nunes, de Souza MatosDenise C

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study reports two cases of life-threatening complications from live attenuated measles and yellow fever vaccines in previously healthy individuals. Both patients had mutations in the IFNAR1 gene, highlighting the importance of considering genetic susceptibility when vaccinating with live attenuated viruses.
Paper Details　
Original Abstract of the Article :
Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in <i>IFNAR2</i>, <i>STAT1</i>, ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719432/

データ提供：米国国立医学図書館（NLM）

Inherited IFNAR1 Deficiency and Vaccine Reactions

Vaccination plays a crucial role in preventing infectious diseases, but in rare cases, live attenuated vaccines can cause severe adverse reactions. This research investigates the role of inherited IFNAR1 deficiency, a rare genetic disorder, in the development of adverse reactions to measles and yellow fever live vaccines. The researchers examined two patients with otherwise healthy backgrounds who experienced severe complications after receiving these vaccines. They used a combination of clinical investigation and genetic analysis to understand the underlying mechanisms.

IFNAR1 Deficiency and Vaccine Complications

The study found that both patients carried loss-of-function variations in the IFNAR1 gene, indicating an inherited deficiency in type I interferon (IFN) immunity. This deficiency was linked to the development of severe vaccine-associated complications, including measles vaccine disease and viscerotropic disease caused by the yellow fever vaccine. The study also demonstrated that the patients' fibroblasts were susceptible to various viruses, including the vaccine strains, in the absence of exogenous type I IFN.

Understanding Vaccine Safety and Individualized Care

This research highlights the importance of considering genetic predisposition when assessing vaccine safety. The findings underscore the need for comprehensive evaluations of patients experiencing adverse reactions to vaccines, including genetic testing to identify potential underlying conditions like IFNAR1 deficiency. This knowledge can lead to individualized care and strategies for preventing severe complications in individuals at risk.

Dr.Camel's Conclusion

This study, like a beacon in the desert, shines a light on the critical role of genetics in vaccine safety. The research emphasizes the importance of personalized medicine, tailoring vaccination strategies to individual needs and genetic backgrounds. It's a reminder that even in a seemingly straightforward process like vaccination, there are intricate complexities that we must carefully consider.

Date :
  1. Date Completed 2020-06-10
  2. Date Revised 2020-06-10
Further Info :

Pubmed ID

31270247

DOI: Digital Object Identifier

PMC6719432

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Languages

English

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