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Gene-Based Dose Optimization in Children.

Author: BishopJeffrey R, BrownJacob T, RamseyLaura B, Van DriestSara L, VearSusan I

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study emphasizes the importance of pharmacogenetics in precision medicine, particularly in pediatrics. Robust data show that genetic variation can significantly impact drug efficacy and toxicity in children. Guidelines for gene-based dose optimization are available for several drugs, and further investigation is needed for many others.
Paper Details　
Original Abstract of the Article :
Pharmacogenetics is a key component of precision medicine. Genetic variation in drug metabolism enzymes can lead to variable exposure to drugs and metabolites, potentially leading to inefficacy and drug toxicity. Although the evidence for pharmacogenetic associations in children is not as extensive ...See full text at original site
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引用元：
https://doi.org/10.1146/annurev-pharmtox-010919-023459

データ提供：米国国立医学図書館（NLM）

Gene-Based Dose Optimization in Children: Tailoring Treatment to the Individual

The field of pharmacogenetics is revolutionizing the way we approach drug therapy, moving beyond one-size-fits-all approaches to a more personalized medicine. This research highlights the importance of genetic testing in children, focusing on gene-based dose optimization. By understanding the genetic variations that influence drug metabolism, clinicians can tailor treatment regimens to individual patients, improving efficacy and minimizing potential side effects.

Genetic Variations: Individualizing Drug Therapy for Children

Imagine a group of travelers crossing the desert, each with different needs and tolerances for the journey. This research emphasizes the importance of understanding individual genetic variations in children, just as each traveler needs personalized provisions for the journey. By tailoring drug therapy based on genetic profiles, clinicians can improve treatment outcomes and minimize the risk of adverse reactions.

Precision Medicine in Pediatrics: The Future of Child Healthcare

This research underscores the growing importance of precision medicine in pediatrics, a field poised to revolutionize child healthcare. By incorporating genetic testing into clinical practice, we can optimize drug therapy for children, improving their health and well-being. It's like providing a personalized map for each traveler, guiding them safely through the complexities of drug therapy and ensuring a successful journey to recovery.

Dr. Camel's Conclusion

This research reminds me of the importance of individualization in every aspect of life, just as each sand dune in the desert has its unique shape and character. By embracing a personalized approach to drug therapy, we can provide optimal care for children, ensuring they navigate the challenges of treatment with safety and confidence.

Date :
  1. Date Completed 2020-11-11
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

31283429

DOI: Digital Object Identifier

10.1146/annurev-pharmtox-010919-023459

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English

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