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Prostate bed irradiation with alternative radio-oncological approaches (PAROS) - a prospective, multicenter and randomized phase III trial.

Author: DebusJuergen, HaefnerMatthias F, HerfarthKlaus, JaekelCornelia, KatayamaSonja, KoerberStefan A, SanderAnja

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study explores the use of hypofractionated radiation therapy, which involves fewer, larger doses of radiation, for prostate cancer. While this approach is becoming common for patients who haven't had prior treatment, its effectiveness for men who have already had surgery for prostate cancer is less clear. The study also examines the potential role of proton therapy, a more precise form of radiation, in treating prostate cancer. Early research using both types of radiation therapy shows promise.
Paper Details　
Original Abstract of the Article :
For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortened treatment period seems to be safe and feasible. However, reliable data is lacking for pos...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617634/

データ提供：米国国立医学図書館（NLM）

CATSPER2: A Key Player in the Labyrinth of Male Fertility

Navigating the complexities of human reproduction is like exploring a vast desert, each grain of sand representing a unique factor contributing to fertility. This study focuses on CATSPER2, a gene crucial for sperm function, and investigates its role in cases of idiopathic male infertility, a condition where the cause of infertility remains elusive. Researchers identified a novel copy number variation (CNV) in CATSPER2, a genetic abnormality that disrupts the gene's normal function, and sought to uncover its impact on male fertility.

CATSPER2 and Its Impact on Sperm Function

The study discovered that the CNV in CATSPER2 leads to significantly reduced levels of CATSPER2 protein in sperm, impacting their ability to penetrate viscous media, undergo hyperactivation, and respond to progesterone. This disruption in sperm function, despite seemingly normal semen parameters, may explain the infertility experienced by the individual in the study.

Considerations for Male Fertility

This research underscores the critical role of genetic factors in male fertility, shedding light on the intricate mechanisms that govern reproductive success. The study's findings highlight the need for comprehensive genetic testing in cases of idiopathic male infertility, as these abnormalities may provide crucial insights into the underlying causes and inform personalized treatment approaches.

Dr.Camel's Conclusion

This study, like a compass guiding us through the complex desert of male infertility, emphasizes the importance of exploring the genetic landscape of reproduction. The discovery of a CNV in CATSPER2 highlights the need for continued investigation into the molecular mechanisms that govern sperm function and the intricate interplay of genetic factors in human fertility. As we delve deeper into the desert of scientific inquiry, we uncover hidden secrets that offer invaluable insights into the mysteries of human reproduction.

Date :
  1. Date Completed 2019-12-27
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

31291969

DOI: Digital Object Identifier

PMC6617634

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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