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Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells.

Author: CantürkZerrin, DikmenMiriş, GökhanerGökhan

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the antileukemic effects of aprepitant and L-733,060, two neurokinin-1 receptor (NK1R) antagonists, on acute and chronic myeloid leukemic cells. Both drugs exhibited significant antiproliferative effects, suggesting potential therapeutic value for these types of leukemia.
Paper Details　
Original Abstract of the Article :
Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients undergoing chemotherapy for cancer. L-733,060 has been shown to have anxiolyti...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31306152

データ提供：米国国立医学図書館（NLM）

Neurokinin-1 Receptor Antagonists: A Novel Approach to Fighting Leukemia

This research explores the potential antileukemic effects of neurokinin-1 receptor (NK1R) antagonists, aprepitant, and L-733,060. It's like finding a new weapon in the desert against a formidable sandstorm of cancer cells. The study utilizes in-vitro experiments to assess the antiproliferative, apoptotic, and colony-forming effects of these antagonists on acute and chronic myeloid leukemic cells. The findings suggest that NK1R antagonists exhibit significant antileukemic activity, offering a potential novel therapeutic avenue for leukemia treatment.

NK1R Antagonists: A Promising Weapon Against Leukemia

This research unveils the potential of NK1R antagonists as a novel therapeutic strategy for leukemia. It's like discovering a hidden wellspring of healing properties in the desert, offering new hope for those battling this challenging disease.

Exploring New Frontiers in Leukemia Treatment: A Constant Quest for Innovation

This study emphasizes the importance of continuous research and innovation in leukemia treatment. It's like a caravan that keeps exploring the desert, seeking new oases of knowledge and therapeutic solutions for a better future.

Dr. Camel's Conclusion

This research highlights the potential of NK1R antagonists as a novel therapeutic approach for leukemia. It's like finding a hidden oasis in the vast desert of cancer research, offering a glimmer of hope for those seeking effective treatment options.
Date :
  1. Date Completed 2020-09-18
  2. Date Revised 2020-09-18
Further Info :

Pubmed ID

31306152

DOI: Digital Object Identifier

00001813-201908000-00006

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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