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Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).

Author: , AylesHelen, BeyersNulda, BockPeter, BondVirginia, BurnsDavid N, BwalyaJustin, Deshmane SistaNirupama, DonnellDeborah, DunbarRory, El-SadrWafaa, EmelLynda, EshlemanSusan H, FidlerSarah, FloydSian, FraserChristophe, GriffithSam, HargreavesJames R, HauckKatharina, HayesRichard J, HoddinottGraeme, JamesAnelet, KosloffBarry, MacleodDavid, MakolaNozizwe, MandlaNomtha, MooreAyana, PhiriMwelwa, Piwowar-ManningEstelle, SabapathyKalpana, SchaapAb, ShanaubeKwame, SimwingaMusonda, SkallandTimothy, VermundSten H, WilsonEthan, YangBlia

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A combination prevention intervention with ART provided according to local guidelines resulted in a 30% lower incidence of HIV infection compared to standard care. Universal testing and treatment reduced the population-level incidence of HIV infection in this trial setting.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are inconsistent. METHODS: In the HPTN 071 (PopART) community-randomized trial conducted from 2013 through 2018, we rand...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587177/

データ提供：米国国立医学図書館（NLM）

Universal Testing and Treatment for HIV Infection

This study delves into the crucial topic of HIV infection and explores a potential strategy for reducing its incidence: universal testing and treatment. The researchers conducted a large-scale community-randomized trial (HPTN 071 PopART) in Zambia and South Africa, comparing different approaches to HIV prevention and treatment. The study found that providing antiretroviral therapy (ART) according to local guidelines resulted in a significant reduction in new HIV infections compared to standard care. However, a universal ART strategy, where ART was provided to all individuals regardless of their HIV status, did not show the same level of effectiveness. While universal testing and treatment did reduce the overall incidence of HIV infection, this finding suggests that a more targeted approach may be needed for optimal results.

The Impact of Universal Testing and Treatment on HIV Incidence

This study provides valuable information about the impact of universal testing and treatment on HIV infection. The research highlights the effectiveness of providing ART according to local guidelines, while emphasizing that a universal ART approach may not be the most efficient strategy. This finding underscores the need for ongoing research to develop optimal strategies for preventing and treating HIV infection.

HIV Prevention and Treatment: A Complex Landscape

This study highlights the complexity of preventing and treating HIV infection. It emphasizes the importance of tailoring interventions to specific populations and contexts. Just as a camel adapts to the different landscapes within the desert, finding the right approach for managing HIV requires a personalized and strategic approach. This research encourages us to continue exploring innovative and effective methods for combatting this global health challenge.

Dr.Camel's Conclusion

This study underscores the need for a nuanced approach to HIV prevention and treatment. While universal testing and treatment have shown benefits, a more targeted strategy, such as providing ART according to local guidelines, may be more effective in certain settings. Remember, just as a camel navigates different terrains within the desert, addressing this complex health issue requires an adaptable and multifaceted approach.
Date :
  1. Date Completed 2019-07-26
  2. Date Revised 2023-04-25
Further Info :

Pubmed ID

31314965

DOI: Digital Object Identifier

PMC6587177

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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