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Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.

Author: ChenWangqing, ChenXiang, LiJie, LiJuan, LiuZhaoqian, PengCong, SuJuan, ZhangWei, ZhuWu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Desloratadine is an antihistamine used to treat chronic spontaneous urticaria (CSU). This study investigated the association between the HRH1 gene rs901865 polymorphism and the severity of sedation side effects following desloratadine treatment. Results showed that the G/G genotype was associated with severe sedation side effects.
Paper Details　
Original Abstract of the Article :
H1 nonsedating antihistamines, such as desloratadine, are first-line treatment options for chronic spontaneous urticaria (CSU). However, desloratadine induces various degrees of sedation side effect in CSU patients, and no biomarkers currently exist for predicting the severity of such side effect. H...See full text at original site
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引用元：
https://doi.org/10.1038/s41397-019-0094-0

データ提供：米国国立医学図書館（NLM）

Desloratadine and Sedation: A Genetic Connection

The world of allergy research is constantly seeking to understand the individual responses to medications. This study investigates the potential association between a genetic polymorphism in the histamine H1 receptor (HRH1) gene and the severity of sedation side effects after desloratadine treatment in patients with chronic spontaneous urticaria (CSU). The researchers [study design] to evaluate the relationship between [specific genetic variation] and [specific side effect] in a group of patients with CSU. Their findings suggest that individuals with a specific genotype may be at higher risk for experiencing sedation side effects after desloratadine treatment. This research provides valuable insights for clinicians seeking to personalize treatment strategies for patients with CSU.

HRH1 Gene Polymorphism: A Potential Predictor of Side Effects

This research highlights the potential importance of genetic factors in predicting side effects from medications. The study found that [specific result], suggesting that a specific genotype may be associated with an increased risk of sedation side effects after desloratadine treatment. This study provides valuable insights for clinicians seeking to personalize treatment strategies for patients with CSU.

Personalized Medicine: Tailoring Treatment to Individual Needs

This research underscores the importance of personalized medicine in addressing health concerns. The findings suggest that [specific recommendation] can be crucial for optimizing treatment outcomes and minimizing side effects. It's a reminder that addressing allergic conditions requires a careful assessment of individual needs and preferences.

Dr.Camel's Conclusion

This research sheds light on the potential role of genetic factors in predicting side effects from medications. The study's findings highlight the importance of personalized medicine and encourage further research to develop genetic tests that can help clinicians tailor treatment strategies to the individual needs of their patients.

Date :
  1. Date Completed 2021-01-04
  2. Date Revised 2022-04-20
Further Info :

Pubmed ID

31406237

DOI: Digital Object Identifier

10.1038/s41397-019-0094-0

SNS
PICO Info
in preparation
Languages

English

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