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Effect of disease duration and prior disease-modifying antirheumatic drug use on treatment outcomes in patients with rheumatoid arthritis.

Author: AletahaDaniel, ChenSu, FlorentinusStefan, FurtnerDaniel, MaaJen-Fue, NichollsDave, ParkSung-Hwan, SmolenJosef S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two randomized controlled trials of patients with established rheumatoid arthritis found that a greater number of prior disease-modifying antirheumatic drugs and longer disease duration were associated with smaller improvements in disease activity and lower American College of Rheumatology response rates.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine if disease duration and number of prior disease-modifying antirheumatic drugs (DMARDs) affect response to therapy in patients with established rheumatoid arthritis (RA). METHODS: Associations between disease duration or number of prior DMARDs and response to therapy were as...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900248/

データ提供：米国国立医学図書館（NLM）

Disease Duration and Prior DMARD Use: Impact on Rheumatoid Arthritis Treatment Outcomes

This study investigates the influence of disease duration and prior disease-modifying antirheumatic drug (DMARD) use on treatment outcomes in patients with established rheumatoid arthritis (RA). The researchers analyzed data from two randomized controlled trials to assess the response to therapy in patients receiving adalimumab plus methotrexate. The study revealed [主要な発見] about the factors affecting treatment response in RA patients. The findings highlight the importance of considering disease duration and prior DMARD use when developing individualized treatment plans for RA patients.

Understanding the Complexities of Rheumatoid Arthritis Management

This research underscores the complex nature of managing rheumatoid arthritis. The observed [研究結果] emphasize the importance of individualizing treatment approaches based on factors such as disease duration and prior DMARD use. This discovery highlights the need for ongoing research into the interplay between these factors and treatment outcomes, ensuring optimal care for individuals with RA.

Managing Rheumatoid Arthritis: A Personalized Approach

This research emphasizes the importance of a personalized approach to managing rheumatoid arthritis. The findings suggest that [日常生活で気をつけるべきことや取り入れるべきこと] can contribute to improved treatment outcomes. By encouraging close collaboration between patients and healthcare professionals, we can develop tailored treatment plans that optimize effectiveness and enhance quality of life for individuals with RA.

Dr. Camel's Conclusion

Just as a camel adapts to the ever-changing desert landscape, we must adapt our treatment strategies for rheumatoid arthritis. This study reminds us that disease duration and prior DMARD use can significantly influence treatment outcomes. We must continue to explore the complexities of RA, seeking innovative solutions and personalized approaches to ensure that patients receive the best possible care, allowing them to navigate their health journey with resilience and strength, like a camel traversing the vast and challenging desert landscape.
Date :
  1. Date Completed 2020-04-09
  2. Date Revised 2020-04-09
Further Info :

Pubmed ID

31434637

DOI: Digital Object Identifier

PMC6900248

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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