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Randomized Population Pharmacokinetic Analysis and Safety of Intravenous Acetaminophen for Acute Postoperative Pain in Neonates and Infants.

Author: CooperDavid S, DevarakondaKrishna, GosselinNathalie H, HammerGregory B, LuJia, MaxwellLynne G, PhengLeng Hong, SzmukPeter, TaicherBrad M, VisoiuMihaela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Intravenous acetaminophen was safe and effective for the treatment of acute postoperative pain in neonate and infant patients.
Paper Details　
Original Abstract of the Article :
Intravenous administration of acetaminophen is an alternative to the oral and rectal routes, which may be contraindicated in particular clinical settings. This randomized, placebo-controlled study of intravenous acetaminophen (Ofirmev, Mallinckrodt Pharmaceuticals, Bedminster, New Jersey) in neonate...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973014/

データ提供：米国国立医学図書館（NLM）

Evolution of TEM-type Extended-Spectrum β-lactamases in Escherichia coli by Cephalosporins

This research explores the intriguing world of bacterial resistance, focusing on the evolution of TEM-type extended-spectrum β-lactamases (ESBLs) in Escherichia coli. The authors meticulously investigated the molecular mechanisms behind the development of resistance to four third-generation cephalosporins: ceftazidime, cefotaxime, ceftriaxone, and ceftibuten. Their findings reveal the complex interplay between antibiotic pressure and bacterial adaptation, providing valuable insights into the ongoing battle against antibiotic resistance.

Antibiotic Resistance: A Battle in the Desert

The study highlights the complex mechanisms behind antibiotic resistance, revealing how bacteria adapt and evolve in the face of antibiotic pressure. The researchers identified specific molecular changes that contribute to the development of ESBLs, providing a deeper understanding of the evolutionary process. This knowledge can inform the development of new strategies to combat antibiotic resistance.

Combating Resistance: A Race Against Time

This study underscores the critical importance of understanding the mechanisms behind antibiotic resistance. The authors emphasize the need for ongoing research to develop new antibiotics and strategies to combat the growing threat of resistant bacteria. This is a race against time, as antibiotic resistance continues to emerge and spread.

Dr.Camel's Conclusion

Imagine the desert as a vast and ever-changing landscape, where bacteria constantly adapt and evolve. This research highlights the intricate mechanisms behind antibiotic resistance, revealing how bacteria can overcome even the most potent antibiotics. Understanding these mechanisms is crucial in our ongoing battle against antibiotic resistance. The researchers are like explorers mapping this ever-shifting desert, seeking to outwit the relentless forces of bacterial evolution.
Date :
  1. Date Completed 2021-02-03
  2. Date Revised 2021-02-03
Further Info :

Pubmed ID

31448420

DOI: Digital Object Identifier

PMC6973014

Related Literature

Article Analysis
・Effects of acetaminophen rectal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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