Paper Details

  1. Home
  2. Paper Details

Effects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin.

Author: ChaoPei-Dawn Lee, HouYu-Chi, HsiehYow-Wen, LinShiuan-Pey, LuoShu-Shang, SweetDouglas H, YuChung-Ping

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that ciprofloxacin significantly increased the area under the curve (AUC) and half-life (T1/2) of indoxyl sulfate (IS) in rats, while decreasing its clearance. This was attributed to ciprofloxacin's inhibition of the OAT3 transporter, which is involved in IS excretion. Other antibiotics like ofloxacin, cefuroxime, cefotaxime, and cefazolin did not affect IS pharmacokinetics. This suggests that ciprofloxacin may interfere with IS removal from the body.
Paper Details　
Original Abstract of the Article :
Indoxyl sulfate (IS), a highly protein-bound nephro-cardiovascular toxin, was poorly removed by hemodialysis. IS exists as anions in the body and the renal excretion is mediated by organic anion transporter 1 (OAT1) and OAT3. Acidic antibiotics such as cephalosporins and fluoroquinolones were putati...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1080/00498254.2019.1660433

データ提供：米国国立医学図書館（NLM）

Antibiotics and Indoxyl Sulfate: A Complex Interplay in the Kidney

Indoxyl sulfate (IS), a potentially harmful toxin, is poorly removed by hemodialysis and can contribute to kidney and cardiovascular complications. This study investigates the effects of various antibiotics on the pharmacokinetics of IS in rats, focusing on the role of organic anion transporters (OATs) in IS elimination. The researchers found that ciprofloxacin, an antibiotic commonly used for bacterial infections, significantly increased IS levels in the blood, potentially hindering its excretion. This finding suggests that ciprofloxacin may compete with IS for OAT-mediated renal excretion, potentially leading to IS accumulation and increased risk of complications. This research highlights the complex interplay between antibiotics and IS, underscoring the need for careful consideration of potential drug interactions and the importance of monitoring IS levels in patients receiving antibiotics.

Antibiotics and Indoxyl Sulfate: A Complex Dance in the Kidney

The study reveals that ciprofloxacin, a commonly prescribed antibiotic, can significantly increase IS levels in the blood, potentially hindering its elimination from the body. This finding raises concerns about potential drug interactions and the importance of monitoring IS levels in patients receiving antibiotics. The research underscores the complex interplay between antibiotics and IS, highlighting the need for cautious consideration of these interactions to minimize potential risks to kidney and cardiovascular health.

Antibiotics and Indoxyl Sulfate: Navigating the Desert of Drug Interactions

This research highlights the importance of understanding potential drug interactions, particularly when dealing with medications that affect kidney function. The study suggests that ciprofloxacin may interfere with the elimination of IS, potentially leading to its accumulation and increased risk of complications. This research encourages a careful and thoughtful approach to antibiotic therapy, considering potential drug interactions and monitoring patient health closely.

Dr.Camel's Conclusion

This study, like a camel navigating the vast desert of drug interactions, reveals the complex interplay between antibiotics and IS. The findings suggest that ciprofloxacin can significantly increase IS levels, highlighting the importance of careful consideration of potential drug interactions and the need for monitoring IS levels in patients receiving antibiotics. This research underscores the importance of a holistic approach to patient care, taking into account potential interactions between medications and their impact on kidney health.

Date :
  1. Date Completed 2020-03-13
  2. Date Revised 2020-03-13
Further Info :

Pubmed ID

31448977

DOI: Digital Object Identifier

10.1080/00498254.2019.1660433

Related Literature

Article Analysis
・Effects of cefotaxime injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.