Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas' disease).

Author: CastroJ A, Diaz de ToranzoE G

Paper Details 
Original Abstract of the Article :
American trypanosomiasis (Chagas' disease) is an endemic parasitic disease afflicting more than 20 million persons in Latin America. Two drugs are currently being used for treatment of the acute phase of Chagas' disease: 4-[(5-nitrofurfurylidene)amino-3-methylthiomorpholine-1,1-di oxide] (Nifurtimox...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3151755

データ提供:米国国立医学図書館(NLM)

Chagas' Disease: A Desert of Parasitic Infection

The desert of Chagas' disease, caused by the parasite Trypanosoma cruzi, is a formidable landscape, affecting millions of people worldwide. This study, like a team of researchers mapping the complex terrain of this disease, investigates the toxic effects of nifurtimox and benznidazole, the two main drugs currently used to treat the acute phase of Chagas' disease. The authors, armed with their scientific knowledge, explore the potential side effects associated with these medications, providing valuable insights into the challenges of treating this neglected tropical disease. Their research highlights the need for safer and more effective treatment options to combat this debilitating parasitic infection.

A Toxic Oasis: Navigating the Side Effects of Chagas' Disease Treatment

The study reveals a complex picture of the toxic effects associated with nifurtimox and benznidazole, highlighting the need for careful monitoring and management of potential side effects. The researchers document a range of adverse effects, including neurological, gastrointestinal, and reproductive complications, highlighting the need for further research to develop safer and more effective treatment options. This research, like a well-worn trail through the desert, provides crucial insights into the complexities of treating Chagas' disease.

Dr. Camel's Conclusion

This study underscores the challenges of treating Chagas' disease, highlighting the potential toxic effects of the current treatment options. The research emphasizes the need for continued research to develop safer and more effective therapies to combat this neglected tropical disease.

Date :
  1. Date Completed 1989-12-05
  2. Date Revised 2018-06-08
Further Info :

Pubmed ID

3151755

DOI: Digital Object Identifier

3151755

Related Literature

SNS
PICO Info
in preparation
Languages

English

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