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Binding affinity data of DNA aptamers for therapeutic anthracyclines from microscale thermophoresis and surface plasmon resonance spectroscopy.

Author: HilleCarsten, HurpinJeanne, KlevesathAnja, MengerMarcus, SassStephan, StöckleinWalter F M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Anthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an important role in cancer treatment, but their chronic administration can cause severe side effects. This study described the detailed characterization of a single-stranded DNA aptamer for DOX and DRN detection.
Paper Details　
Original Abstract of the Article :
Anthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an undisputed key role in cancer treatment, but their chronic administration can cause severe side effects. For precise anthracycline analytical systems, aptamers are preferable recognition elements. Here, we describe the detailed cha...See full text at original site
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引用元：
https://doi.org/10.1039/c9an01247h

データ提供：米国国立医学図書館（NLM）

Binding Affinity Data of DNA Aptamers for Therapeutic Anthracyclines

Anthracyclines are powerful drugs used in cancer treatment. This study explored the potential of DNA aptamers, short single-stranded DNA sequences that bind to specific targets, as recognition elements for precise anthracycline analytical systems. The researchers characterized a single-stranded DNA aptamer and its truncated versions for the detection of daunorubicin (DRN) and doxorubicin (DOX). The study utilized various techniques, including surface plasmon resonance (SPR) and microscale thermophoresis (MST), to determine binding affinities and conformational data.

Aptamers as Recognition Elements for Anthracyclines

The study found that both aptamers displayed similar nanomolar binding affinities to DRN and DOX, despite differences in rate constants. This suggests that DNA aptamers have the potential to be valuable tools for developing precise analytical systems for anthracycline detection.

Understanding the Promise of Aptamers

Aptamers are a rapidly evolving field in medicine. Their ability to bind to specific targets with high affinity makes them promising candidates for diagnostics, therapeutics, and other applications.

Dr. Camel's Conclusion

This research offers a glimpse into the fascinating world of aptamers. Like a skilled navigator finding a hidden treasure in the desert of molecular biology, the authors have uncovered the potential of DNA aptamers as recognition elements for anthracyclines. This discovery paves the way for the development of more precise and effective analytical systems for cancer treatment.

Date :
  1. Date Completed 2020-01-07
  2. Date Revised 2020-01-07
Further Info :

Pubmed ID

31528891

DOI: Digital Object Identifier

10.1039/c9an01247h

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Languages

English

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