A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics.

Author: BordoniLuca, FrischeSebastian, JiménezEugenio Gutiérrez, NielsenSøren, ØstergaardLeif

Paper Details 
Original Abstract of the Article :
The most used experimental mouse model of hyponatremia and elevated intracranial pressure (ICP) is intraperitoneal injection of water in combination with antidiuretics. This model of water intoxication (WI) results in extreme pathological changes and death within 1 h. To improve preclinical studies ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004811/

データ提供:米国国立医学図書館(NLM)

Water Intoxication: A New Model for Studying Increased Intracranial Pressure

This research focuses on water intoxication, a potentially dangerous condition caused by excessive water consumption, like a camel drinking too much water after a long trek through the desert. The study developed a new mouse model to study the effects of water intoxication, particularly its impact on intracranial pressure (ICP). The researchers found that their new model effectively simulates increased ICP, but without the extreme side effects of traditional models.

A New Model for Studying ICP

This study introduces a novel and more refined mouse model to study water intoxication and its impact on ICP. It's like a camel breeder, carefully selecting and refining a new breed of camel to withstand harsh desert conditions. This new model will allow for more accurate and reliable research on the pathophysiology of increased ICP. The study highlights the potential of this new model to advance our understanding of ICP and its consequences.

Water Intoxication: Understanding the Risks

The study emphasizes the potential risks associated with water intoxication. Just as a camel needs to carefully regulate its water intake in the desert, humans should be aware of the dangers of excessive water consumption. This research encourages further investigation into the mechanisms behind water intoxication and its implications for health.

Dr.Camel's Conclusion

This research is a testament to the ongoing efforts to improve our understanding of complex medical conditions. The development of a new and more accurate model for studying water intoxication is a significant step forward. Just as a camel adapts to its surroundings, we can continuously refine our methods to better understand and address health challenges.

Date :
  1. Date Completed 2020-04-20
  2. Date Revised 2020-04-20
Further Info :

Pubmed ID

31534063

DOI: Digital Object Identifier

PMC7004811

Related Literature

SNS
PICO Info
in preparation
Languages

English

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