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Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission with Topical Combination of Ketamine and Diphenhydramine.

Author: AgrawalMahima, GoldustMohamad, SonthaliaSidharth, TalwarAnkur

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case report explored the use of a topical diphenhydramine/ketamine (DK) cream for maintaining remission in a patient with Hailey-Hailey disease (HHD) who had previously achieved remission with oral low-dose naltrexone (LDN). The DK cream allowed for a reduction in LDN dosage, eventually leading to successful withdrawal of LDN without relapse. This suggests that topical agents with anti-inflammatory and antipruritic properties may be a useful adjunct in the management of HHD.
Paper Details　
Original Abstract of the Article :
Recent anecdotal evidence suggests that oral low-dose naltrexone (LDN) is effective for Hailey-Hailey disease (HHD) but suffers the limitation of immediate relapse following cessation of the medication. With lack of safety data on long-term administration of LDN, we explored the utility of a topical...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743391/

データ提供：米国国立医学図書館（NLM）

Low-Dose Naltrexone for Hailey-Hailey Disease: A Desert Oasis of Hope

The field of dermatology is constantly searching for effective treatments for challenging conditions. This study dives into the intriguing world of Hailey-Hailey disease (HHD), a rare genetic skin disorder. The researchers investigated the potential of low-dose naltrexone (LDN) as a treatment for HHD, utilizing a unique approach. They employed a topical cream containing diphenhydramine and ketamine to maintain remission achieved with LDN. The authors discovered that this combination could indeed help maintain remission after LDN was discontinued.

The Power of Topical Therapy: A Refreshing Change

The study found that the topical cream, containing diphenhydramine and ketamine, effectively maintained remission after LDN was discontinued. This suggests that a topical approach may be a viable alternative to long-term oral LDN therapy.

A Glimpse into the Future of HHD Treatment

These findings present a promising avenue for the treatment of HHD, suggesting that topical therapy could offer a valuable alternative to long-term oral LDN. This could improve the quality of life for individuals with HHD by minimizing potential side effects associated with long-term LDN use.

Dr.Camel's Conclusion

This research, like a cool oasis in the hot desert, offers a glimmer of hope for HHD patients. The researchers' innovative approach of combining topical agents with LDN has the potential to revolutionize HHD treatment. This is an exciting development in the search for more effective and well-tolerated therapies for this challenging condition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-06-29
Further Info :

Pubmed ID

31544078

DOI: Digital Object Identifier

PMC6743391

Related Literature

Article Analysis
・Effects of diphenhydramine topical
SNS
PICO Info
in preparation
Languages

English

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