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Postmastectomy radiotherapy in T1-2 patients with one to three positive lymph nodes - Past, present and future.

Author: BernierJacques, KaššákFilip, PicardiCristina, RossierChristine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The role of post-mastectomy radiotherapy (PMRT) for patients with small tumors and positive lymph nodes after axillary dissection is debated. This review discusses existing evidence and ongoing research, including the SUPREMO trial, which may provide more definitive guidance on PMRT indication.
Paper Details　
Original Abstract of the Article :
PAST: The role of post-mastectomy radiotherapy (PMRT) in patients with tumor <5 cm and one to three positive lymph nodes after axillary dissection (ALND) is vigorously debated. Initial doubts over the efficacy and safety of PMRT in these patients were partially overcome by improvement in technology ...See full text at original site
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引用元：
https://doi.org/10.1016/j.breast.2019.09.008

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Post-Mastectomy Radiotherapy: A Journey Through Time

The field of oncology is constantly evolving, seeking new ways to treat cancer effectively while minimizing side effects. This research explores the role of post-mastectomy radiotherapy (PMRT) in patients with early-stage breast cancer. Specifically, it examines the debate surrounding the use of PMRT in patients with one to three positive lymph nodes after axillary dissection (ALND). This research takes a historical approach, analyzing the past, present, and future of PMRT in this context.

A Balancing Act: Choosing the Right Path in the Desert of Treatment Options

The evidence regarding PMRT in N1 patients is complex, with some studies suggesting its benefit while others raise concerns. The Early Breast Cancer Trialists' Collaborative Group (EBCTCG) meta-analysis provides strong evidence supporting the use of PMRT in N1 patients. However, more recent studies, though retrospective, suggest that PMRT might not be necessary for all N1 patients, and patient selection should be tailored to individual risk factors. This is like choosing the right path through a vast desert – some paths might be safer or more efficient than others, depending on your specific needs and circumstances.

The Future of PMRT: A Journey Through the Sands of Time

The upcoming results of the SUPREMO trial in 2023 will shed light on the optimal approach to PMRT in N1 patients. Additionally, genomic tumor cell profiling will likely provide further guidance on risk stratification. It's an exciting time in the field of breast cancer treatment, as advancements in technology and research continue to shape the landscape of care. It's like watching the dunes shift and change in the desert, constantly revealing new possibilities.

Dr.Camel's Conclusion

The debate surrounding PMRT in N1 patients is complex and ongoing. The evidence suggests that a one-size-fits-all approach is not optimal, and individualized risk assessment is crucial. With the evolving landscape of breast cancer treatment, it's important to stay informed and consult with your doctor to make the best decisions for your health.

Date :
  1. Date Completed 2020-04-10
  2. Date Revised 2020-04-10
Further Info :

Pubmed ID

31561088

DOI: Digital Object Identifier

10.1016/j.breast.2019.09.008

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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