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The effects of mitotane and 1&#945;,25-dihydroxyvitamin D<sub>3</sub> on Wnt/beta-catenin signaling in human adrenocortical carcinoma cells.

Author: FalloF, PezzaniR, PilonC, RebellatoA, RubinB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of mitotane and 1α,25(OH)2D3, individually and in combination, on H295R adrenocortical carcinoma cells in vitro. The study aimed to elucidate the molecular mechanisms behind these effects, particularly focusing on the Wnt/β-catenin signaling pathway.
Paper Details　
Original Abstract of the Article :
Label="PURPOSE" NlmCategory="OBJECTIVE">Mitotane is the only chemotherapeutic agent available for the treatment of adrenocortical carcinoma (ACC), however, the anti-neoplastic efficacy is limited due to several side-effects in vivo. There is, therefore, a need of exploring for new anti-tumoral agent...See full text at original site
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引用元：
https://doi.org/10.1007/s40618-019-01127-1

データ提供：米国国立医学図書館（NLM）

Exploring New Therapies for Adrenocortical Carcinoma: The Synergy of Mitotane and Vitamin D

This research delves into the challenging world of cancer treatment, specifically focusing on adrenocortical carcinoma (ACC). The study explores the potential of combining mitotane, the only chemotherapeutic agent currently available for ACC, with the active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). The researchers investigated the effects of these agents individually and in combination on H295R ACC cells, focusing on their impact on the Wnt/β-catenin signaling pathway, a crucial pathway involved in cancer development. The study found that both mitotane and 1α,25(OH)2D3 exhibited anti-proliferative effects on ACC cells, suggesting their potential as synergistic agents in ACC therapy.

Potential for Synergistic Treatment of Adrenocortical Carcinoma

The study's findings suggest that combining mitotane with 1α,25(OH)2D3 could enhance the effectiveness of ACC treatment. The synergistic effects of these agents, observed through their impact on the Wnt/β-catenin signaling pathway, warrant further investigation as a potential new approach to combat this challenging cancer.

The Health Implications and Practical Applications

This research could lead to the development of new and more effective treatment strategies for ACC, potentially improving patient outcomes and quality of life. The combination of mitotane and 1α,25(OH)2D3 could offer a more targeted and effective approach to combat this aggressive cancer, providing hope for patients in need.

Dr.Camel's Conclusion

This research, like a desert oasis providing a refreshing respite, offers a new approach to treating ACC. The potential synergy of mitotane and vitamin D could be a game-changer in the fight against this challenging cancer.

Date :
  1. Date Completed 2020-11-20
  2. Date Revised 2022-02-28
Further Info :

Pubmed ID

31587178

DOI: Digital Object Identifier

10.1007/s40618-019-01127-1

SNS
PICO Info
in preparation
Languages

English

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