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The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism.

Author: DammannGerhard, GründerGerhard, HaenEkkehard, HiemkeChristoph, KuzinMaxim, PaulzenMichael, SchoretsanitisGeorgios

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Adding pantoprazole to an ongoing treatment with clozapine did not alter the metabolism of clozapine.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. METHODS: A large therapeutic drug-monitoring database containing plasma concentra...See full text at original site
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引用元：
https://doi.org/10.1055/a-1021-8827

データ提供：米国国立医学図書館（NLM）

Unraveling the Complex Web of Medications: Clozapine Metabolism and Pantoprazole

The world of medications can be a labyrinth of interactions, where different drugs can influence each other's effects. This study explores the potential impact of pantoprazole, a proton pump inhibitor commonly used to treat heartburn, on the metabolism of clozapine, an antipsychotic medication. The researchers analyzed a large database of patients receiving clozapine, comparing those who were also taking pantoprazole to those who were not. They found no significant changes in clozapine metabolism in patients taking pantoprazole, suggesting that these two medications can likely be co-prescribed safely.

Navigating the Labyrinth of Medications: Understanding Drug Interactions

This study highlights the importance of understanding potential drug interactions. The researchers investigated the impact of pantoprazole, a common medication for heartburn, on the metabolism of clozapine, an antipsychotic. Their findings suggest that co-prescription of these two drugs is unlikely to significantly alter the effectiveness of clozapine, providing valuable information for clinicians managing patients taking both medications.

Protecting the Oasis of Mental Health: Collaborating with Your Doctor

The study emphasizes the importance of open communication with your doctor about all medications you are taking. It is crucial to inform your healthcare provider about any changes in medications or the emergence of new symptoms to ensure optimal treatment and prevent potential drug interactions.

Dr. Camel's Conclusion

This study sheds light on the complex world of drug interactions, highlighting the importance of careful monitoring and communication between patients and their healthcare providers. The findings suggest that co-prescription of pantoprazole and clozapine is unlikely to significantly impact clozapine's effectiveness. However, it is always essential to be aware of potential drug interactions and discuss any concerns with your doctor.

Date :
  1. Date Completed 2020-12-07
  2. Date Revised 2020-12-14
Further Info :

Pubmed ID

31614374

DOI: Digital Object Identifier

10.1055/a-1021-8827

Related Literature

Article Analysis
・Effects of pantoprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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