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Stability behaviour of antiretroviral drugs and their combinations. 11: Characterization of interaction products of zidovudine and efavirenz, and evaluation of their anti HIV-1 activity, and physiochemical and ADMET properties.

Author: BalharaAnkit, GargPrabha, KulkarniSmita, KurmiMoolchand, SahuArchana, SinghInder Pal, SinghNavneet Kumar, SinghSaranjit

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the potential interaction between zidovudine (ZDV) and efavirenz (EFV), two antiretroviral drugs. Two new cycloaddition products were identified and evaluated for their cytotoxicity and in vitro anti-HIV-1 activity. The products showed weak activity against HIV-1, potentially due to their larger molecular size.
Paper Details　
Original Abstract of the Article :
Zidovudine (ZDV) and efavirenz (EFV), which belong to two separate classes of antiretroviral drugs, viz., NRTI and NNRTI, respectively, were subjected to different stability test conditions alone and in solid mixtures to evaluate possibility of interaction among them. The exposed samples were analyz...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2019.112911

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Drug Interactions: Zidovudine and Efavirenz

The development of new drugs for HIV treatment is like navigating a vast desert, searching for hidden oases of therapeutic efficacy. This study investigates the potential interactions between zidovudine (ZDV), a nucleoside reverse transcriptase inhibitor (NRTI), and efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), commonly used in HIV treatment. The researchers exposed mixtures of ZDV and EFV to various stability test conditions and found that they can interact to form novel cycloaddition products. These products, though found to have weak anti-HIV-1 activity, raise concerns about potential drug interactions and the need for careful monitoring during combination therapy.

Drug Interactions: A Potential Pitfall in HIV Treatment

The study underscores the importance of considering potential drug interactions when prescribing HIV medications. The formation of novel compounds suggests that drug interactions can occur even when combining drugs from different classes.

Navigating the Drug Desert: A Call for Vigilance

This research highlights the need for careful monitoring of drug interactions in HIV patients. Clinicians should be vigilant in assessing potential drug interactions and adjust treatment plans accordingly to ensure optimal therapeutic outcomes.

Dr. Camel's Conclusion

The desert of HIV treatment is vast and complex, with drug interactions being a potential pitfall. This study reminds us that navigating this desert requires careful attention to potential drug interactions and vigilant monitoring of patient responses.

Date :
  1. Date Completed 2020-06-04
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

31627078

DOI: Digital Object Identifier

10.1016/j.jpba.2019.112911

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Languages

English

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