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Effects of meclofenamate on breathing movements in fetal sheep before delivery.

Author: ClymanR I, KittermanJ A, LeeC H, MaurayF E, MuraiD T, WallenL D

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Meclofenamate, a prostaglandin synthase inhibitor, caused a significant decrease in [PGE2] and a significant increase in FBM in eight fetal sheep, suggesting that the decrease in FBM before delivery is not dependent on the concurrent increase in [PGE2].
Paper Details　
Original Abstract of the Article :
There is evidence that prostaglandins (PG), specifically PGE2, participate in the regulation of fetal breathing movements (FBM). During late gestation, when FBM occur intermittently and primarily during low-voltage electrocortical activity, the concentration of PGE2 in fetal plasma ([PGE2]) is high....See full text at original site
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引用元：
https://doi.org/10.1152/jappl.1988.64.2.759

データ提供：米国国立医学図書館（NLM）

Fetal Breathing Movements: A Dance with Prostaglandins

This research explores the fascinating and complex world of fetal development, specifically focusing on fetal breathing movements (FBM) and their intricate relationship with prostaglandins (PG). The authors investigate the role of PGE2, a key PG, in regulating FBM during late gestation. They use fetal sheep as a model to explore the effects of inhibiting PG synthesis on FBM.

What Does this Study Suggest?

The study suggests that the decrease in FBM before delivery is not dependent on the concurrent increase in [PGE2]. It’s like a sandstorm that temporarily blocks the sun but doesn’t change the underlying climate. This study sheds light on the complex interplay of factors regulating FBM and adds to our understanding of fetal development.

Implications for Health and Lifestyle

This study offers valuable insights into the complex process of fetal development, highlighting the interplay of different biological factors. Understanding this process is crucial for ensuring optimal fetal health and well-being.

Dr.Camel's Conclusion

This research is a testament to the intricate and fascinating world of fetal development. It reminds us that even in the seemingly simple act of breathing, there’s a complex symphony of biological events at play.

Date :
  1. Date Completed 1988-06-27
  2. Date Revised 2017-12-13
Further Info :

Pubmed ID

3163687

DOI: Digital Object Identifier

10.1152/jappl.1988.64.2.759

Related Literature

Article Analysis
・Effects of meclofenamate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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