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Ultrasound-assisted gatifloxacin delivery in mouse cornea, in vivo.

Author: JegalUk, JeongHyerin, KimKi Hean, KimMyoung Joon, LeeJun Ho, LeeJungbin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study demonstrated that ultrasound treatment effectively enhanced the trans-corneal delivery of gatifloxacin in mouse corneas, potentially reducing the amount or frequency of daily doses needed for ocular infection treatment.
Paper Details　
Original Abstract of the Article :
Gatifloxacin is a 4th generation fluoroquinolone antibiotic used in the clinic to treat ocular infection. One limitation of gatifloxacin is its relatively poor corneal penetration, and the increase of its trans-corneal delivery would be beneficial to reduce the amount or frequency of daily dose. In ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820539/

データ提供：米国国立医学図書館（NLM）

Ultrasound: A New Ally in Eye Infection Treatment

Gatifloxacin, a powerful antibiotic, is a valuable tool in the fight against [ocular infections]. However, its [limited corneal penetration] can hinder its effectiveness. This research explores the potential of [ultrasound] to enhance the [trans-corneal delivery] of gatifloxacin, improving its ability to reach the target site and combat infection.

Ultrasound: A Force Multiplier for Gatifloxacin Delivery

The authors demonstrate that [ultrasound treatment] can significantly improve the [penetration of gatifloxacin] into the cornea, potentially leading to [more effective treatment] of ocular infections. This finding could lead to [reduced doses and frequency of administration], improving patient convenience and potentially reducing side effects.

Caring for Your Eyes: Recognizing and Treating Eye Infections

Eye infections can be [painful and disruptive] to daily life. This research highlights the importance of [innovative approaches] to treating these infections, ensuring that patients receive the most effective and safe treatment possible. By exploring new ways to enhance drug delivery, we can strive to [minimize the impact] of eye infections on our vision and overall well-being.

Dr.Camel's Conclusion

Just as a camel can navigate the scorching desert sands, ultrasound can help gatifloxacin navigate the challenging terrain of the cornea, reaching the infection site and effectively combating the threat. This research highlights the potential of ultrasound to revolutionize the treatment of ocular infections, providing a powerful tool for ophthalmologists and enhancing patient outcomes.

Date :
  1. Date Completed 2020-10-28
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31664145

DOI: Digital Object Identifier

PMC6820539

Related Literature

Article Analysis
・Effects of gatifloxacin ophthalmic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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