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PPARA/RXRA signalling regulates the fate of hepatic non-esterified fatty acids in a sheep model of maternal undernutrition.

Author: GuoChangzheng, HuFan, MaoShengyong, XueYanfeng, ZhuWeiyun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Maternal undernutrition during late gestation can lead to lipid metabolism disorders in offspring. This study investigated the regulatory role of PPARA/RXRA signaling in hepatic lipid metabolism in an undernourished sheep model. Results showed that lipid transport and metabolism were significantly altered in the undernourished group, with upregulation of fatty acid oxidation and ketogenesis and downregulation of fatty acid synthesis. The PPARA/RXRA signaling pathway was identified as a key regulator of hepatic lipid metabolism in this context.
Paper Details　
Original Abstract of the Article :
Maternal undernutrition during late gestation accelerates body fat mobilization to provide more energy for foetal growth and development, which unbalances metabolic homeostasis and results in serious lipid metabolism disorder. However, detailed regulatory mechanisms are poorly understood. Here, a sh...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbalip.2019.158548

データ提供：米国国立医学図書館（NLM）

Unraveling the Complexities of Lipid Metabolism: PPARA/RXRA Signaling in Maternal Undernutrition

This study delves into the intricate world of lipid metabolism, investigating the role of PPARA/RXRA signaling in regulating hepatic non-esterified fatty acids (NEFAs) in a sheep model of maternal undernutrition. It's like exploring a vast desert landscape, where each dune represents a different aspect of this complex metabolic process.

PPARA/RXRA Signaling: A Vital Regulator in the Desert of Metabolism

Maternal undernutrition during late gestation can disrupt metabolic homeostasis, leading to lipid metabolism disorders. The study revealed that PPARA/RXRA signaling plays a critical role in regulating hepatic lipid metabolism, influencing fatty acid transport, oxidation, triglyceride metabolism, and other metabolic processes. It's like a delicate ecosystem in the desert, where each element plays a vital role in maintaining balance and survival.

A Journey of Discovery: Uncovering the Mechanisms of NEFAs and BHBA

The study found that NEFAs activate PPARA signaling, promoting fatty acid oxidation (FAO) and ketogenesis. Conversely, beta-hydroxybutyric acid (BHBA) inhibits RXRA signaling, suppressing FAO and ketogenesis. These findings provide crucial insights into the mechanisms by which these molecules influence hepatic lipid metabolism. It's like uncovering hidden pathways in the desert, revealing the interconnectedness of different metabolic processes.

Dr.Camel's Conclusion

This study sheds light on the intricate role of PPARA/RXRA signaling in regulating hepatic lipid metabolism, particularly in the context of maternal undernutrition. It's like unveiling a complex web of interactions within a vast desert ecosystem. The findings offer valuable insights into the mechanisms of NEFAs and BHBA, potentially paving the way for new strategies to maintain lipid metabolic homeostasis and combat metabolic disorders.
Date :
  1. Date Completed 2020-05-12
  2. Date Revised 2020-05-18
Further Info :

Pubmed ID

31676441

DOI: Digital Object Identifier

10.1016/j.bbalip.2019.158548

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English

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