Paper Details

  1. Home
  2. Paper Details

Screening for drugs to reduce zebrafish aggression identifies caffeine and sildenafil.

Author: ClealMadeleine, GutiérrezHéctor Carreño, NortonWilliam H J, O'ConnorBethan, ParkerMatthew O, SchoenmackerGido, TochwinAnna, VaccaIrene, VasquezAlejandro Arias, WinterMatthew J, YoungAndrew M J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study used a zebrafish model to identify drugs that could reduce aggression without affecting locomotion. Caffeine and sildenafil were identified as potential candidates. Caffeine reduced aggression but also decreased attention and increased impulsivity. Sildenafil had the opposite effect, increasing attention and reducing impulsivity. These findings suggest that zebrafish are a valuable model for screening novel drugs to treat aggression.
Paper Details　
Original Abstract of the Article :
Although aggression is a common symptom of psychiatric disorders the drugs available to treat it are non-specific and can have unwanted side effects. In this study we have used a behavioural platform in a phenotypic screen to identify drugs that can reduce zebrafish aggression without affecting loco...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.euroneuro.2019.10.005

データ提供：米国国立医学図書館（NLM）

Zebrafish: A New Model for Studying Aggression and Finding Anti-Aggression Drugs?

Aggression, a complex behavior often associated with mental health challenges, is a difficult problem to address. This research explores the potential of zebrafish as a model system for studying aggression and identifying potential anti-aggression drugs. The authors conducted a phenotypic screen using a behavioral platform in zebrafish, discovering that caffeine and sildenafil can selectively reduce aggression. Their findings suggest that zebrafish could be a valuable tool for drug discovery, offering a new avenue for developing more targeted treatments for aggression-related disorders.

Zebrafish: A New Frontier in Aggression Research?

The authors' findings provide evidence that zebrafish can be a useful model for studying aggression and for screening potential anti-aggression drugs. The identification of caffeine and sildenafil as potential anti-aggression agents, along with their distinct effects on other cognitive functions, opens up exciting new avenues for research and drug development. The study also highlights the potential of zebrafish as a model for studying the neural mechanisms underlying aggression.

The Quest for Better Treatments: Understanding Aggression

The complexities of aggression continue to be a challenge for researchers and clinicians. This research provides valuable insights into the potential of zebrafish as a model for studying aggression and for developing novel treatments. The findings suggest that zebrafish could be a valuable tool in the search for more effective and targeted interventions for aggression-related disorders.

Dr.Camel's Conclusion

You know, just like how a camel can be docile but can also be fierce when protecting its territory, zebrafish offer a fascinating model for studying aggression. This research highlights the potential of this little fish to help us understand the complex mechanisms of aggression and to develop new and effective treatments. It's a reminder that sometimes, the most unexpected sources can hold the key to unlocking new knowledge and finding solutions to challenging problems.

Date :
  1. Date Completed 2021-04-22
  2. Date Revised 2021-04-22
Further Info :

Pubmed ID

31679888

DOI: Digital Object Identifier

10.1016/j.euroneuro.2019.10.005

Related Literature

Article Analysis
・Side Effects of sildenafil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.