[Five-week subacute intravenous toxicity study of cefodizime sodium in dogs].

Author: HirotaT, IrimuraK, KurokawaK, MoritaK, NakanoS, YadaH

Paper Details 
Original Abstract of the Article :
A subacute toxicity study of cefodizime sodium (THR-221), a new cephem antibiotics, was carried out using male and female beagle dogs. THR-221 was intravenously administered to the dog at dose levels of 500, 1000 and 2000 mg/kg/day for 5 weeks, followed by 4 weeks recovery period. Cefotetan (CTT) as...See full text at original site
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引用元:
https://doi.org/10.2131/jts.13.supplementi_43

データ提供:米国国立医学図書館(NLM)

Cefodizime Sodium: A New Cephem Antibiotic Under the Microscope

This study investigates the safety of cefodizime sodium, a new cephem antibiotic, in dogs. It's like studying a new desert plant, examining its potential benefits and potential risks. The researchers conducted a subacute toxicity study, administering cefodizime sodium intravenously to beagle dogs at varying doses for five weeks. They observed mild side effects, such as vomiting and salivation, at higher doses but no significant impact on body weight, food consumption, or overall health.

Cefodizime Sodium: A Promising Antibiotic with a Favorable Safety Profile

The study reveals that cefodizime sodium possesses a favorable safety profile, demonstrating minimal toxicity in dogs even at high doses. It's like finding a desert flower that thrives even in harsh conditions. This finding suggests that cefodizime sodium has the potential to be a safe and effective antibiotic for treating bacterial infections.

Cefodizime Sodium: A Potential Alternative to Existing Antibiotics

This research highlights the potential of cefodizime sodium as a new antibiotic option. It's like discovering a new oasis in the desert, offering a valuable resource for combating bacterial infections. The study's findings suggest that cefodizime sodium may be a safer alternative to existing cephem antibiotics, potentially offering a broader therapeutic range.

Dr. Camel's Conclusion

This study provides valuable insights into the safety and efficacy of cefodizime sodium, a promising new antibiotic. It's like venturing into a new desert landscape, uncovering a potentially valuable resource. The findings suggest that cefodizime sodium may be a safe and effective alternative to existing antibiotics, offering hope for the treatment of bacterial infections.

Date :
  1. Date Completed 1988-11-23
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3172296

DOI: Digital Object Identifier

10.2131/jts.13.supplementi_43

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PICO Info
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Languages

Japanese

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