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Efficacy, safety, and tolerability of mirabegron in patients aged ≥65yr with overactive bladder wet: a phase IV, double-blind, randomised, placebo-controlled study (PILLAR).

Author: EngelEli, HerschornSender, KristyRita M, SchermerCarol R, StaskinDavid, WaggAdrian

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mirabegron was effective, safe, and tolerable in patients aged ≥65 years with overactive bladder (OAB) and incontinence, demonstrating improvement in OAB symptoms over 12 weeks.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The majority of patients with overactive bladder (OAB) are aged >65yr. There has been no prospectively designed study assessing treatment efficacy with the β3-adrenoreceptor agonist, mirabegron, specifically in this age group. OBJECTIVE: A phase IV study comparing flexibly dosed mirabeg...See full text at original site
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引用元：
https://doi.org/10.1016/j.eururo.2019.10.002

データ提供：米国国立医学図書館（NLM）

Mirabegron for Overactive Bladder in Older Adults

This study investigated the effectiveness and safety of mirabegron, a medication for overactive bladder (OAB), in older adults. The researchers conducted a double-blind, randomized, placebo-controlled trial, a rigorous approach to evaluate the drug’s effects. They found that mirabegron significantly improved OAB symptoms in older adults, including reducing the frequency of urination and episodes of incontinence.

Improving Quality of Life for Older Adults

This study offers a beacon of hope for older adults who suffer from OAB. Mirabegron, like a refreshing sip of water in the desert, can provide much-needed relief from the troublesome symptoms of OAB.

Empowering Older Adults

This study is a testament to the ongoing efforts to improve the quality of life for older adults. By developing effective treatments for common conditions like OAB, we can empower older adults to live healthier and more fulfilling lives.

Dr.Camel's Conclusion

This study demonstrates the efficacy and safety of mirabegron for treating overactive bladder in older adults. It is a reminder that we must continue to invest in research to find effective solutions for the unique needs of our aging population.

Date :
  1. Date Completed 2021-03-18
  2. Date Revised 2021-03-18
Further Info :

Pubmed ID

31733990

DOI: Digital Object Identifier

10.1016/j.eururo.2019.10.002

Related Literature

Article Analysis
・Side Effects of mirabegron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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