Side Effects of mirabegron: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main Research Findings

Mirabegron, a medication for overactive bladder, has shown to be safer and have fewer side effects compared to anticholinergics. 5 , 27 Its effectiveness has also been confirmed in elderly patients. 3 Mirabegron belongs to a new class of drugs called β3-adrenergic receptor agonists, which work by relaxing the muscles in the bladder, thereby improving overactive bladder symptoms. 6 Compared to anticholinergics, mirabegron has been reported to have fewer side effects such as dry mouth, constipation, and blurred vision. 5 However, mirabegron can potentially cause side effects such as urinary retention and tachycardia. 4 , 11

Reasons for Side Effects

The side effects of mirabegron are due to its agonist activity on β3-adrenergic receptors. β3-adrenergic receptors are found not only in the bladder muscles but also in the heart and blood vessels. Therefore, mirabegron can potentially increase heart rate and blood pressure in addition to relaxing the bladder muscles. 11

Common Side Effects

Urinary Retention

Urinary retention has been reported as a side effect of mirabegron. 4 The risk of urinary retention may be higher in men with benign prostatic hypertrophy. 4

Tachycardia

Tachycardia has been reported as a side effect of mirabegron. 11 Mirabegron acts on the β3-adrenergic receptors of the heart and can potentially increase heart rate. 11

Other Side Effects

Other side effects of mirabegron reported include headache, indigestion, constipation, and back pain. 5

Countermeasures for Side Effects

Urinary Retention

If urinary retention occurs, stop taking mirabegron and consult your doctor. 4 Your doctor will investigate the cause of urinary retention and provide appropriate treatment. 4

Tachycardia

If tachycardia occurs, stop taking mirabegron and consult your doctor. 11 Your doctor will investigate the cause of tachycardia and provide appropriate treatment. 11

Other Side Effects

If any other side effects occur, stop taking mirabegron and consult your doctor. 5 Your doctor will investigate the cause of the side effect and provide appropriate treatment. 5

Comparison Among Studies

Commonalities

Numerous studies have shown that mirabegron is an effective treatment for overactive bladder. 6 , 9 , 3 , 12 Furthermore, it has been reported to have fewer side effects compared to anticholinergics. 5 , 13

Differences

Different studies have reported varying incidence and types of side effects related to mirabegron. 4 , 11 This is likely due to variations in study participants such as age, gender, and underlying health conditions. 4 , 11

Precautions for Real-Life Applications

Mirabegron is an effective treatment for overactive bladder, but it can cause side effects. 5 , 13 It is crucial to consult your doctor before taking mirabegron to ensure it is suitable for your body. 5 , 13 If you experience any side effects such as urinary retention or tachycardia while taking mirabegron, contact your doctor immediately. 4 , 11

Current Research Limitations

There are not yet sufficient studies on the long-term safety and efficacy of mirabegron. 5 , 13 Additionally, it has been reported that the incidence and types of side effects of mirabegron can vary significantly among individuals. 4 , 11

Future Research Directions

Research is needed to evaluate the long-term safety and efficacy of mirabegron. 5 , 13 Further studies are also required to investigate the incidence and types of side effects related to mirabegron in greater detail. 4 , 11

Conclusion

Mirabegron has been shown to be an effective treatment for overactive bladder. 5 , 6 However, there is a possibility of side effects such as urinary retention and tachycardia. 4 , 11 When taking mirabegron, it is crucial to consult your doctor and fully understand the risks of side effects before starting the medication. 5 , 13

Literature analysis of 28 papers
Positive Content
25
Neutral Content
2
Negative Content
1
Article Type
6
2
2
9
28
1.

Side effects of minocycline: different dosage regimens.

Author: GumpD W, AshikagaT, FinkT J, RadinA M

Lower dose effective
Nausea

Minocycline at doses of 150 mg and 200 mg per day had similar side effect profiles in women. Volunteers taking 150 mg had lower serum concentrations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Side effects of minocycline: a double-blind study.

Author: FanningW L, GumpD W, SoffermanR A

High incidence of side effects in women
Vestibular side effects

Minocycline caused a higher incidence of side effects in women than men. This may be related to higher serum concentrations in women, which could be due to their smaller size.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Efficacy, safety, and tolerability of mirabegron in patients aged ≥65yr with overactive bladder wet: a phase IV, double-blind, randomised, placebo-controlled study (PILLAR).

Author: WaggAdrian, StaskinDavid, EngelEli, HerschornSender, KristyRita M, SchermerCarol R

Mirabegron
OAB treatment
Overactive bladder
Urgency incontinence

Mirabegron was effective, safe, and tolerable in patients aged ≥65 years with overactive bladder (OAB) and incontinence, demonstrating improvement in OAB symptoms over 12 weeks.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[MIRABEGRON--A NEW DRUG FOR TREATMENT OF OVERACTIVE BLADDER].

Author: KasjanG R

OAB treatment

Mirabegron, a beta-3 adrenergic agonist, is a new oral therapy for overactive bladder (OAB). It is approved for use in Europe and North America and is effective in treating urge urinary incontinence, urgency, and urinary frequency.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

6.

Profile of mirabegron in the treatment of overactive bladder: place in therapy.

Author: SharafAla'a, HashimHashim

Treatment of overactive bladder
Adverse effects

Mirabegron is a new drug for treating overactive bladder syndrome. It can be used alone or in combination with other treatments. Studies have shown that mirabegron is effective and well-tolerated, but some potential side effects are of concern. This review summarizes the clinical trials on mirabegron, its pharmacokinetics, mechanism of action, and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Potential of Mirabegron and its Extended-release Formulations for the Treatment of Overactive Bladder Syndrome.

Author: MandpePankaj, PrabhakarBala, ShendePravin

Overactive bladder treatment
Blurred vision
Constipation
Dizziness
Dry mouth

Mirabegron, a β3-adrenoreceptor agonist, is a new treatment option for overactive bladder syndrome (OAB). It offers advantages over traditional antimuscarinic drugs with its superior potency, tolerability, and lower incidence of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Persistence and compliance with medication management in the treatment of overactive bladder.

Author: KimTae Heon, LeeKyu-Sung

OAB symptom control
Medication discontinuation

Overactive bladder (OAB) is a common and chronic condition. This review discusses factors that affect medication persistence and compliance in patients with OAB, highlighting the importance of addressing unmet expectations and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

The risk and severity of developing symptomatic palpitations when prescribed mirabegron for overactive bladder.

Author: BalachandranAswini A, DuckettJonathan R A

Overactive Bladder Treatment
Palpitations

Mirabegron is a drug used to treat overactive bladder. This study investigated the risk of developing palpitations while taking mirabegron. The study found that mirabegron was well-tolerated and there was no increased risk of developing palpitations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

A randomized, controlled trial of effectiveness and safety of management of OAB symptoms in elderly men and women with standard-dosed combination of solifenacin and mirabegron.

Author: KosilovKirill, LoparevSergay, IvanovskayaMarina, KosilovaLiliya

Overactive bladder treatment
Side effects

This study compared the effectiveness and safety of solifenacin, mirabegron, and their combination in patients with severe symptoms of overactive bladder. The study found that the combination of solifenacin and mirabegron provided satisfactory therapeutic effects within a short period of time without increasing the risk of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Brown Fat and Nutrition: Implications for Nutritional Interventions.

Author: NoriegaLloyd, YangCheng-Ying, WangChih-Hao

Brown fat activation
Metabolic disease prevention
Drug side effects

This review discusses the potential of brown and beige adipocytes as targets for addressing metabolic diseases. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Mirabegron versus Solifenacin in Children with Overactive Bladder: Prospective Randomized Single-Blind Controlled Trial.

Author: SolimanMohamed G, El-AbdShawky, El-GamalOsama M, RaheemAli Abdel, Abou-RamadanAhmed R, El-AbdAhmed S

Improved OAB symptoms
Constipation
Dry mouth

Both mirabegron and solifenacin showed comparable efficacy in controlling overactive bladder (OAB) symptoms in newly diagnosed children, with mirabegrone having less side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Dual Therapy for Refractory Overactive Bladder in Children: A Prospective Open-Label Study.

Author: MorinFannie, BlaisAnne-Sophie, NadeauGeneviève, MooreKatherine, GenoisLucie, BolducStéphane

Urinary incontinence treatment

This study investigated the efficacy and safety of mirabegron, a β3 adrenoreceptor agonist, as an add-on therapy for urinary incontinence in children with idiopathic overactive bladder who were refractory or intolerant to antimuscarinics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Safety and efficacy of mirabegron in daily clinical practice: a prospective observational study.

Author: KallnerHelena Kopp, ChristenssonAnna Almén, ElmérCaroline, FlamBenjamin, AltmanDaniel

Mirabegron effective
Mirabegron safe

Mirabegron is a safe treatment option for overactive bladder in women. It is associated with a decrease in systolic blood pressure but there were no significant changes in heart rate, diastolic blood pressure, or QTc interval.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

22.

Efficacy and safety of mirabegron, a β3-adrenoceptor agonist, for treating neurogenic bladder in pediatric patients with spina bifida: a retrospective pilot study.

Author: ParkJee Soo, LeeYong Seung, LeeCho Nyeong, KimSung Hoon, KimSang Woon, HanSang Won

Neurogenic bladder treatment

This study evaluated the efficacy and safety of mirabegron, a new β-3 adrenoceptor agonist, for treating neurogenic bladder in children with spina bifida.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

[Urinary incontinence in geriatric patients: pharmacological Therapy].

Author: WiedemannAndreas, BecherKlaus, BojackBarbara, EgeSigrid, von der HeideSilke, Kirschner-HermannsRuth

This document is a part of a guideline about urinary incontinence in frail elderly patients. It focuses on pharmacological therapy for this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

24.

The efficacy and safety of mirabegron on overactive bladder induced by benign prostatic hyperplasia in men receiving tamsulosin therapy: A systematic review and meta-analysis.

Author: SuShunye, LinJinlei, LiangLiqin, LiuLudong, ChenZhipeng, GaoYuan

Mirabegron efficacy
OAB treatment
Increased post-void residual urine

The meta-analysis found that mirabegron was effective and well-tolerated in treating overactive bladder (OAB) induced by benign prostatic hyperplasia (BPH) in men receiving tamsulosin therapy. However, mirabegron was associated with an increased risk of post-void residual urine volume.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Effect of mirabegron on cognitive function in elderly patients with overactive bladder: MoCA results from a phase 4 randomized, placebo-controlled study (PILLAR).

Author: GrieblingTomas L, CampbellNoll L, MangelJeffrey, StaskinDavid, HerschornSender, ElsoudaDina, SchermerCarol R

Overactive bladder treatment
Cognitive effects

Antimuscarinics are commonly used to treat overactive bladder (OAB) but can cause cognitive impairment. This study evaluated the cognitive effects of mirabegron, a β3-adrenoreceptor agonist, compared to placebo in older adults with OAB.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Mirabegron: The most promising adipose tissue beiging agent.

Author: BelJocelyn S, TaiT C, KhaperNeelam, LeesSimon J

Improve glucose metabolism
Metabolic improvement
Reduce LD size
Cardiovascular side effects

Mirabegron is a drug that activates brown fat tissue, which can help to improve metabolism. This review discusses the potential benefits of mirabegron for the treatment of obesity and type 2 diabetes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Efficacy of overactive neurogenic bladder treatment: A systematic review of randomized controlled trials.

Author: BapirRawa, BhattiKamran Hassan, EliwaAhmed, García-PerdomoHerney Andrés, GherabiNazim, HennesseyDerek, MagriVittorio, MourmourisPanagiotis, OuattaraAdama, PerlettiGianpaolo, PhiliprajJoseph, StamatiouKonstantinos, TrinchieriAlberto, BuchholzNoor

Neurogenic OAB treatment
Pharmacological treatments

This meta-analysis reviewed the efficacy of pharmacological and non-pharmacological treatments for neurogenic overactive bladder. The results suggest that anticholinergics, mirabegron, transcutaneous tibial nerve stimulation (TTNS), and pelvic floor muscle training (PFMT) all show moderate efficacy. The study highlights the need for further research to establish the superiority of one treatment over another and the potential benefits of combination therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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