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Prescription of benzodiazepines, z-drugs, and gabapentinoids and mortality risk in people receiving opioid agonist treatment: Observational study based on the UK Clinical Practice Research Datalink and Office for National Statistics death records.

Author: CornishRosie, HickmanMatthew, MacleodJohn, MarsdenJohn, MillarTim, SteerColin, StrangJohn, TillingKate

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the relationship between benzodiazepine prescriptions and mortality risk in patients receiving opioid agonist treatment (OAT) for opioid dependency. The researchers hypothesized that benzodiazepines would increase mortality risk, regardless of any increased treatment duration.
Paper Details　
Original Abstract of the Article :
Patients with opioid dependency prescribed opioid agonist treatment (OAT) may also be prescribed sedative drugs. This may increase mortality risk but may also increase treatment duration, with overall benefit. We hypothesised that prescription of benzodiazepines in patients receiving OAT would incre...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879111/

データ提供：米国国立医学図書館（NLM）

Benzodiazepines, Z-Drugs, and Gabapentinoids: Navigating the Desert of Opioid Agonist Treatment

The desert of opioid agonist treatment is a complex and challenging landscape, where patients often face a variety of co-occurring conditions. This study investigates the potential risks associated with prescribing benzodiazepines, z-drugs, and gabapentinoids to patients receiving opioid agonist treatment (OAT).

The researchers found that prescription of benzodiazepines in patients receiving OAT was associated with an increased risk of mortality, even when considering the potential benefits of increased treatment duration. It's like navigating a desert with a compass that sometimes points in the wrong direction.

The Importance of Careful Medication Management

This study highlights the importance of careful medication management in patients receiving OAT. The researchers found that benzodiazepine prescription was associated with an increased risk of mortality, suggesting that these drugs should be used with caution in this population. It's a reminder that even seemingly safe medications can have unexpected consequences when used in combination with other drugs.

Navigating the Risks and Benefits of OAT

This study provides valuable insights into the risks and benefits of OAT. It's a reminder that we need to carefully weigh the potential benefits of medication against the potential risks, especially when treating complex conditions.

Dr.Camel's Conclusion

This study underscores the importance of careful medication management in patients receiving OAT. It suggests that benzodiazepines should be used with caution in this population and that careful monitoring is essential to minimize the risk of adverse outcomes.

Date :
  1. Date Completed 2020-02-07
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31770388

DOI: Digital Object Identifier

PMC6879111

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