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[Clinical and fundamental studies on ceftriaxone (CTRX) against urinary tract infections].

Author: NishioS, YoshiharaH

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ceftriaxone (CTRX) was effective in 85% of patients with complicated urinary tract infections. While serum levels were very high in patients with chronic renal failure, CTRX was well tolerated and did not cause severe side effects.
Paper Details　
Original Abstract of the Article :
Clinical efficacy of ceftriaxone (CTRX) against complicated urinary tract infections in 20 patients was examined, and the serum CTRX level was also measured in the patients with chronic renal failure (CRF). CTRX was administered at a dose of 1.0 g once a day for 5 to 10 days. The overall clinical ef...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3177133

データ提供：米国国立医学図書館（NLM）

Ceftriaxone: A Powerful Weapon Against Urinary Tract Infections

This article delves into the effectiveness of ceftriaxone (CTRX) in treating complicated urinary tract infections (UTIs), exploring its efficacy and pharmacokinetics. It's like venturing into the desert of UTIs, searching for a potent weapon to combat this common infection.

Ceftriaxone's Effectiveness: A Promising Remedy

The study found that CTRX was clinically effective in treating complicated UTIs, with an overall efficacy rate of 85%. It successfully eradicated 62.8% of isolated strains after administration. These findings demonstrate the potential of CTRX as a valuable treatment option for UTIs.

Navigating the Desert of Renal Failure

The study also assessed CTRX's pharmacokinetics in patients with chronic renal failure (CRF), finding that CTRX levels remained high and plateaued after injection. This suggests that CTRX may not be effectively removed by hemodialysis, a crucial factor to consider when treating patients with CRF.

Dr.Camel's Conclusion

This study underscores the importance of considering both efficacy and pharmacokinetics when choosing an antibiotic for treating UTIs, particularly in patients with renal impairment. It's like navigating a desert landscape with diverse terrain, requiring a customized approach based on the specific challenges presented. Ceftriaxone offers a promising remedy for UTIs, but its use in patients with CRF requires careful monitoring and consideration.
Date :
  1. Date Completed 1988-11-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3177133

DOI: Digital Object Identifier

3177133

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